Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy.
Int J Mol Sci. 2020 Jan 30;21(3):922. doi: 10.3390/ijms21030922.
CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation. In contrast to these pro-tumorigenic functions, CD155 is also a ligand for the activating receptor DNAM-1 expressed on cytotoxic lymphocytes including Natural Killer (NK) cells and involved in anti-tumor immune response. However, during tumor progression inhibitory receptors for CD155 are up-regulated on the surface of effector cells, contributing to an impairment of their cytotoxic capacity. In this review we will focus on the roles of CD155 as a ligand for the activating receptor DNAM-1 regulating immune surveillance against cancer and as pro-oncogenic molecule favoring tumor proliferation, invasion and immune evasion. A deeper understanding of the multiple roles played by CD155 in cancer development contributes to improving anti-tumor strategies aimed to potentiate immune response against cancer.
CD155 是一种黏附分子，属于 Nectin/Nectin 样家族，在肿瘤细胞上常常过表达，并参与许多不同的过程，如细胞黏附、迁移和增殖。与这些促进肿瘤发生的功能相反，CD155 也是表达在细胞毒性淋巴细胞（包括自然杀伤（NK）细胞）上的激活受体 DNAM-1 的配体，参与抗肿瘤免疫反应。然而，在肿瘤进展过程中，抑制性受体在效应细胞表面上调，导致其细胞毒性能力受损。在这篇综述中，我们将重点讨论 CD155 作为激活受体 DNAM-1 的配体的作用，调节对癌症的免疫监视，以及作为促进肿瘤增殖、侵袭和免疫逃逸的致癌分子。深入了解 CD155 在癌症发展中所扮演的多种角色，有助于改善旨在增强抗肿瘤免疫反应的抗癌策略。
