与多发性硬化症相关的葡萄膜炎的临床发现与预后
Clinical findings and outcomes of uveitis associated with multiple sclerosis.
作者信息
AlBloushi Abdulrahman F, Dheyab Abdulsalam M, Al-Swaina Nayef F, Al-Obailan Majed, Daif Abdul-Kader, Abu El-Asrar Ahmed M
机构信息
Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Division of Neurology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
出版信息
Eur J Ophthalmol. 2021 Mar;31(2):482-490. doi: 10.1177/1120672120904667. Epub 2020 Feb 4.
PURPOSE
To describe the clinical findings and outcomes in patients who presented with uveitis associated with multiple sclerosis.
METHODS
Retrospective review of 20 patients (38 eyes).
RESULTS
The most frequent ocular finding was multifocal elongated retinal perivenous "sheathing" with focal vascular leakage on fundus fluorescein angiography in 29 eyes followed by vitreous snowballs and debris in 26 eyes, anterior chamber inflammation in 15 eyes, mutton-fat keratic precipitates in 14 eyes, posterior synechiae in 13 eyes, cystoid macular edema in 9 eyes, iris nodules in 4 eyes, and optic neuritis in 3 eyes. Patients with cystoid macular edema were treated successfully with systemic corticosteroids combined with mycophenolate mofetil. Ocular complications were cataract in 6 eyes, glaucoma in 2 eyes and vitreous hemorrhage in 1 eye.
CONCLUSIONS
Multifocal elongated retinal perivenous "sheathing" with focal vascular leakage on fundus fluorescein angiography is the most frequent finding in uveitis associated with multiple sclerosis.
目的
描述患有与多发性硬化相关葡萄膜炎的患者的临床发现及预后。
方法
对20例患者（38只眼）进行回顾性研究。
结果
最常见的眼部表现为29只眼中可见多灶性视网膜静脉周围细长“鞘膜”伴眼底荧光血管造影局部血管渗漏，其次为26只眼中的玻璃体雪球样混浊和混浊物、15只眼中的前房炎症、14只眼中的羊脂状角膜后沉着物、13只眼中的虹膜后粘连、9只眼中的黄斑囊样水肿、4只眼中的虹膜结节以及3只眼中的视神经炎。黄斑囊样水肿患者采用全身用皮质类固醇联合霉酚酸酯治疗成功。眼部并发症包括6只眼发生白内障、2只眼发生青光眼以及1只眼发生玻璃体出血。
结论
眼底荧光血管造影显示多灶性视网膜静脉周围细长“鞘膜”伴局部血管渗漏是与多发性硬化相关葡萄膜炎最常见的表现。
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