Ophthalmology, Barzilai Medical Center, Askelon, Israel.
Faculty of Health Science, Ben Gurion University of the Negev, Beersheba, Israel.
PLoS One. 2022 Jun 29;17(6):e0264918. doi: 10.1371/journal.pone.0264918. eCollection 2022.
An association between uveitis and multiple sclerosis (MS) is well-established, but the actual nature of that association remains poorly understood. We sought to determine the association between the presence of a uveitis diagnosis prior to an MS diagnosis compared to no pre-existing uveitis diagnosis in MS patients.
Patients in whom the presentation of uveitis preceded the presentation of MS (study group) and patients with MS and no uveitis (control group) were randomly selected at a ratio of 1:3 from the Sheba Multiple Sclerosis Center computerized database.
Eleven patients presented with uveitis prior to MS diagnosis (study group), and 31 randomly selected patients had MS without uveitis (control group). Only one patient in the study group deteriorated to EDSS 3 during the follow-up period, compared to 15 patients in the control group (9.1% vs 48.4%, P = 0.049). None of the patients in the study group reached EDSS 6 during the 10 years of follow-up compared to 6 (19.4%) patients in the control group (P = 0.194).
MS patients who presented with uveitis that preceded their neurological symptoms of MS demonstrated a clinically significant better neurological prognosis, than our MS patients with no uveitis.
葡萄膜炎与多发性硬化症（MS）之间存在关联已得到充分证实，但这种关联的实际性质仍知之甚少。我们旨在确定与 MS 患者中存在 MS 诊断前的葡萄膜炎诊断相比，无预先存在的葡萄膜炎诊断之间的关联。
在 Sheba 多发性硬化症中心计算机数据库中，以 1:3 的比例随机选择葡萄膜炎先于 MS 表现（研究组）和 MS 无葡萄膜炎的患者（对照组）。
11 例患者在 MS 诊断前出现葡萄膜炎（研究组），31 例随机选择的患者在 MS 无葡萄膜炎（对照组）。与对照组相比，研究组中只有 1 例患者在随访期间恶化至 EDSS 3（9.1%比 48.4%，P = 0.049）。在 10 年的随访中，研究组中没有患者达到 EDSS 6，而对照组中有 6 例（19.4%）（P = 0.194）。
与无葡萄膜炎的 MS 患者相比，表现为 MS 神经症状前葡萄膜炎的 MS 患者具有明显更好的神经预后。
