父母温暖与多个基因相互作用，影响执行功能成分：一项全基因组环境交互作用研究。

Parental warmth interacts with several genes to affect executive function components: a genome-wide environment interaction study.

机构信息

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.

Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China.

出版信息

BMC Genet. 2020 Feb 4;21(1):11. doi: 10.1186/s12863-020-0819-8.

BACKGROUND

Executive function (EF) is vital to human beings. It has been linked to many genes and family environmental factors in separate studies, but few studies have examined the potential interactions between gene(s) and environmental factor(s). The current study explored the whole genome to identify SNPs, genes, and pathways that interacted with parental warmth (PW) on EF.

RESULTS

Nine EF tasks were used to measure its three components (common EF, updating, shifting) based on the model proposed by Miyake et al. (2000). We found that rs111605473, LAMP5, SLC4A7, and LRRK1 interacted significantly with PW to affect the updating component of EF, and the GSE43955 pathway interacted significantly with PW to affect the common EF component.

CONCLUSIONS

The current study is the first to identify genes that interacted with PW to affect EF. Further studies are needed to reveal the underlying mechanism.

背景

执行功能（EF）对人类至关重要。在单独的研究中，它已与许多基因和家庭环境因素相关联，但很少有研究探讨基因与环境因素之间的潜在相互作用。本研究探索了整个基因组，以确定与父母温暖（PW）相互作用影响 EF 的 SNPs、基因和途径。

结果

根据 Miyake 等人提出的模型（2000 年），使用九项 EF 任务来衡量其三个组成部分（通用 EF、更新、转换）。我们发现 rs111605473、LAMP5、SLC4A7 和 LRRK1 与 PW 显著相互作用，影响 EF 的更新成分，GSE43955 途径与 PW 显著相互作用，影响通用 EF 成分。