Nielsen R
Acta Vet Scand. 1988;29(1):67-75. doi: 10.1186/BF03548394.
Vaccination of pigs with a killed culture of A. pleuropneumoniae serotype 5, strain K17 (subtype a) afforded a high degree of protection against challenge with strains L20 and T928 (subtype b). The reverse experiment showed that strain L20 gave good protection against challenge with strain K17 whereas strain T928 did not afford an acceptable protection against challenge with this strain. The considerable cross immunity shown to exist between strains K17 and L20 indicates a high degree of homogeneity of the antigenic determinants of the two strains involved in induction of protective immunity and suggest that antibodies to capsular subtype specific determinants may not play a significant role in the specific defence against A. pleuropneumoniae strains belonging to serotype 5. The finding that a vaccine prepared from strain T928 did not afford an acceptable protection against challenge with strain K17 indicates a variable expression among serotype 5 strains of the antigenic determinants which induce protective immunity against A. pleuropneumoniae infection.
用胸膜肺炎放线杆菌血清型5的K17株（a亚型）的灭活培养物对猪进行免疫接种，可使其对L20株和T928株（b亚型）的攻击产生高度保护。反向实验表明，L20株对K17株的攻击提供了良好的保护，而T928株对该株的攻击未提供可接受的保护。K17株和L20株之间存在的显著交叉免疫表明，参与诱导保护性免疫的这两种菌株的抗原决定簇具有高度同质性，并表明针对荚膜亚型特异性决定簇的抗体在针对血清型5的胸膜肺炎放线杆菌菌株的特异性防御中可能不发挥重要作用。由T928株制备的疫苗对K17株的攻击未提供可接受的保护这一发现表明，血清型5菌株中诱导针对胸膜肺炎放线杆菌感染的保护性免疫的抗原决定簇存在可变表达。
