School of Physical Education, Sport & Exercise Sciences, University of Otago, Dunedin, New Zealand.
Department of Exercise & Sport Science, Chapel Hill, NC, USA.
Eur J Cancer Care (Engl). 2020 Jul;29(4):e13231. doi: 10.1111/ecc.13231. Epub 2020 Feb 5.
Cardiovascular disease is the leading cause of death in breast cancer survivors. While evidence shows circuit resistance training (CRT) is effective for improving muscle and cardiorespiratory fitness, whether CRT is an efficacious therapy for decreasing cardiovascular risk in cancer survivors is unclear.
Fifty-one breast cancer survivors were recruited to either 12 weeks CRT (n = 26), or a non-exercising wait-list control (n = 25). Two supervised 60 min CRT sessions per week were undertaken, comprising resistance and functional exercises, and aerobic exercise stations. Primary outcome measure was the gold-standard assessment of arterial stiffness, aortic pulse wave velocity (PWV). Secondary outcomes included: cardiorespiratory fitness (CRF), upper and lower body strength, arterial wave reflections, central blood pressure and rate pressure product.
Compared to the control group, the CRT group had a statistically significant medium effect decrease in PWV 0.9 m/s (95% CI: 0.1, 1.7). There were large effect improvements in VO max (4.3 ml kg min , 95% CI: 5.8, 2.8), upper and lower body strength (3.7 kg, 95% CI: 1.9, 5.6 and 10.4 kg, 1.6, 19.1) respectively.
Findings support the existing literature demonstrating that 12 weeks CRT improves muscle and cardiorespiratory fitness and is also an effective strategy for decreasing a proven cardiovascular risk factor in breast cancer survivors.
心血管疾病是乳腺癌幸存者的主要死亡原因。虽然有证据表明，循环电阻训练（CRT）有助于改善肌肉和心肺功能适应性，但 CRT 是否是降低癌症幸存者心血管风险的有效治疗方法尚不清楚。
招募了 51 名乳腺癌幸存者，分别接受 12 周 CRT（n=26）或不进行运动的候补对照组（n=25）。每周进行 2 次 60 分钟的 CRT 监督课程，包括阻力和功能性运动以及有氧运动站。主要结局指标是动脉僵硬度的金标准评估，即主动脉脉搏波速度（PWV）。次要结局包括：心肺功能适应性（CRF）、上下肢力量、动脉波反射、中心血压和心率乘积。
与对照组相比，CRT 组的 PWV 有统计学意义的中等程度下降 0.9m/s（95%CI：0.1，1.7）。VO max 有很大的改善（4.3ml·kg -1 ·min -1 ，95%CI：5.8，2.8），上下肢力量也有很大的提高（3.7kg，95%CI：1.9，5.6和 10.4kg，1.6，19.1）。
这些发现支持了现有的文献，证明 12 周的 CRT 可以提高肌肉和心肺功能适应性，也是降低乳腺癌幸存者已证实心血管风险因素的有效策略。
