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J Orthop. 2019 Nov 27;19:9-13. doi: 10.1016/j.jor.2019.11.034. eCollection 2020 May-Jun.
2
In vitro elution characteristics of commercially and noncommercially prepared antibiotic PMMA beads.市售及非市售抗生素聚甲基丙烯酸甲酯（PMMA）微珠的体外洗脱特性
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Loading with vancomycin does not decrease gentamicin elution in gentamicin premixed bone cement.万古霉素负载不会降低庆大霉素预混骨水泥中庆大霉素的洗脱量。
J Mater Sci Mater Med. 2017 Jul;28(7):104. doi: 10.1007/s10856-017-5915-6. Epub 2017 May 22.

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本文引用的文献

1
Loading with vancomycin does not decrease gentamicin elution in gentamicin premixed bone cement.万古霉素负载不会降低庆大霉素预混骨水泥中庆大霉素的洗脱量。
J Mater Sci Mater Med. 2017 Jul;28(7):104. doi: 10.1007/s10856-017-5915-6. Epub 2017 May 22.
2
[Early Results of Adjuvant Topical Treatment of Recurrent Osteomyelitis with Absorbable Antibiotic Carriers].[可吸收抗生素载体辅助局部治疗复发性骨髓炎的早期结果]
Z Orthop Unfall. 2017 Feb;155(1):35-44. doi: 10.1055/s-0042-112228. Epub 2017 Jan 12.
3
Comparison of the elution properties of commercially available gentamicin and bone cement containing vancomycin with 'home-made' preparations.市售庆大霉素和含万古霉素骨水泥与“自制”制剂洗脱特性的比较。
Bone Joint J. 2017 Jan;99-B(1):73-77. doi: 10.1302/0301-620X.99B1.BJJ-2016-0566.R1.
4
The use of calcium carbonate beads containing gentamicin in the second stage septic revision of total knee arthroplasty reduces reinfection rate.
Knee. 2016 Mar;23(2):322-6. doi: 10.1016/j.knee.2015.12.001. Epub 2016 Jan 13.
5
Local antibiotic therapy strategies in orthopaedic trauma: Practical tips and tricks and review of the literature.骨科创伤中的局部抗生素治疗策略：实用技巧及文献综述
Injury. 2015 Aug;46(8):1447-56. doi: 10.1016/j.injury.2015.05.008. Epub 2015 May 14.
6
Antibiotic-loaded calcium carbonate/calcium sulfate granules as co-adjuvant for bone grafting.负载抗生素的碳酸钙/硫酸钙颗粒作为骨移植的辅助剂
J Mater Sci Mater Med. 2015 Jan;26(1):5344. doi: 10.1007/s10856-014-5344-8. Epub 2015 Jan 13.
7
Bone grafts as carriers for local antibiotic delivery for the treatment and prevention of bone infections.
Surg Technol Int. 2014 Nov;25:239-45.
8
Calcium carbonate powder containing gentamicin for mixing with bone grafts.含庆大霉素的碳酸钙粉末，用于与骨移植材料混合。
Orthopedics. 2014 Aug;37(8):e669-72. doi: 10.3928/01477447-20140728-50.
9
Bone infections and bone graft substitutes for local antibiotic therapy.用于局部抗生素治疗的骨感染与骨移植替代物
Surg Technol Int. 2014 Mar;24:353-62.
10
Gentamicin in bone cement: A potentially more effective prophylactic measure of infectionin joint arthroplasty.骨水泥中的庆大霉素：关节置换术感染的一种潜在更有效的预防性措施。
Bone Joint Res. 2013 Oct 15;2(10):220-6. doi: 10.1302/2046-3758.210.2000188. Print 2013.

庆大霉素从聚甲基丙烯酸甲酯和骨移植替代物中的洗脱：市售制剂与自制制剂的比较。

Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations.

作者信息

Karaglani Makrina, Tzitzikou Evmorfia, Tottas Stylianos, Kougioumtzis Ioannis, Arvanitidis Konstantinos, Kolios George, Chatzaki Ekaterini, Drosos Georgios I

机构信息

Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Greece.

出版信息

J Orthop. 2019 Nov 27;19:9-13. doi: 10.1016/j.jor.2019.11.034. eCollection 2020 May-Jun.

DOI:10.1016/j.jor.2019.11.034
PMID:32021027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6994795/
Abstract

Polymethylmethacrylate (PMMA) represents the current gold standard as an antibiotic delivery carrier in orthopaedic surgery. Despite the accepted use of local antibiotic carriers, there aren't any conclusive data comparing PMMA to Bone Graft Substitutes. The aim of this study was to compare the elution profile of gentamicin from various preparations of PMMA cements and Herafill beads. All cements had high initial elution during the first hour which then slowly decreased, Herafill beads on the other hand showed its higher elution around the eighth hour. Herafill, in general, presented the highest elution of gentamicin regardless of its input amount.

摘要

聚甲基丙烯酸甲酯（PMMA）是目前骨科手术中抗生素递送载体的金标准。尽管局部抗生素载体已被广泛使用，但尚无确凿数据将PMMA与骨移植替代物进行比较。本研究的目的是比较庆大霉素从各种PMMA骨水泥制剂和Herafill珠中的洗脱情况。所有骨水泥在最初一小时内都有较高的初始洗脱量，随后缓慢下降，而Herafill珠在大约第八小时显示出较高的洗脱量。总体而言，无论输入量如何，Herafill的庆大霉素洗脱量最高。