Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin 150080, People's Republic of China.
Int J Nanomedicine. 2020 Jan 21;15:401-418. doi: 10.2147/IJN.S201208. eCollection 2020.
Ultrasound-mediated targeted delivery (UMTD), a novel delivery modality of therapeutic materials based on ultrasound, shows great potential in biomedical applications. By coupling ultrasound contrast agents with therapeutic materials, UMTD combines the advantages of ultrasound imaging and carrier, which benefit deep tissue penetration and high concentration aggregation. In this paper we introduced recent advances in ultrasound contrast agents and applications in tumor therapy. Ultrasound contrast agents were categorized by their functions, mainly including thermosensitive, pH-sensitive and photosensitive ultrasound contrast agents. The various applications of UMTD in tumor treatment were summarized as follows: drug therapy, transfection of anti-oncogene, RNA interference, vaccine immunotherapy, monoclonal antibody immunotherapy, adoptive cellular immunotherapy, cytokine immunotherapy, and so on. In the end, we elaborated on the current challenges and provided perspectives of UMTD for clinical applications.
超声介导靶向递药（UMTD），一种基于超声的治疗材料的新型递药方式，在生物医学应用中显示出巨大的潜力。通过将超声造影剂与治疗材料结合，UMTD 结合了超声成像和载体的优势，有利于穿透深部组织和高浓度聚集。本文介绍了超声造影剂的最新进展及其在肿瘤治疗中的应用。超声造影剂按功能分类，主要包括热敏、pH 敏感和光敏感超声造影剂。UMTD 在肿瘤治疗中的各种应用如下：药物治疗、反义基因转染、RNA 干扰、疫苗免疫治疗、单克隆抗体免疫治疗、过继细胞免疫治疗、细胞因子免疫治疗等。最后，我们详细阐述了目前的挑战，并对 UMTD 的临床应用前景进行了展望。
