a Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging , The Third Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
J Drug Target. 2019 Jan;27(1):33-50. doi: 10.1080/1061186X.2018.1464012. Epub 2018 Apr 27.
As a non-invasive and real-time diagnostic technique, ultrasound has provided a novel strategy for targeted treatment. With the rapid development of ultrasonic technique and ultrasound contrast agents (UCAs), spatiotemporally controllable application of ultrasound with or without UCAs makes it possible for site-specific delivery of therapeutic agents and targeted modulation with minimal side effects, which indicated a promising therapy in clinical use. This review will describe the main mechanism of targeted therapy induced by ultrasound briefly, then focus on the current application of ultrasound mediated targeted therapy in various fields including tumour, cardiovascular disease, central nervous system, skeletal muscle system diseases and stem cells therapy. In addition, ongoing challenges of ultrasound-mediated targeted therapy for further research and its clinical use are reviewed.
作为一种非侵入性和实时的诊断技术，超声为靶向治疗提供了一种新策略。随着超声技术和超声造影剂（UCAs）的快速发展，时空可控的超声应用或联合 UCAs 的应用使得治疗剂的靶向传递和靶向调节成为可能，且副作用最小化，这在临床应用中显示出了很有前景的治疗效果。本综述将简要描述超声靶向治疗的主要机制，然后重点介绍超声介导的靶向治疗在肿瘤、心血管疾病、中枢神经系统、骨骼肌系统疾病和干细胞治疗等各个领域的当前应用。此外，还综述了超声介导的靶向治疗的一些挑战，为进一步的研究和临床应用提供参考。
