Möller C, Odkvist L M, Thell J, Larsby B, Hydén D
Boys Town National Institute, Omaha, Nebraska.
Am J Otol. 1988 Sep;9(5):383-91.
Fifteen patients with disabling Meniere's disease were treated with local intratympanic administration of gentamicin once daily. They had suffered from frequent attacks of vertigo and vomiting, the hearing in the affected ears was decreased permanently, and spontaneous nystagmus was observed. The number of treatment days ranged between 3 and 11. Follow-up time was 1 to 6 years. For evaluation of the treatment, audiologic and vestibular examinations were used, including the broad frequency-band rotatory test (0.4-4.5 Hz). Fourteen patients were free from vertigo after treatment. In 5 patients, there was an increased hearing loss, and in 10 it remained unchanged. Tinnitus and fullness sensations were diminished. After treatment, all ears were unresponsive to caloric stimulation. The clinical examination and rotatory testing in light with sinusoidal stimulation revealed good central compensation of the vestibular loss. However, with pseudorandomized oscillations in darkness, the broad frequency-band rotatory test quantified the loss of peripheral vestibular function and was able to detect the side of the lesion in eight of nine patients.
15例梅尼埃病致残患者接受了鼓室内局部注射庆大霉素治疗，每日1次。他们频繁发作眩晕和呕吐，患耳听力永久性下降，并观察到自发性眼球震颤。治疗天数为3至11天。随访时间为1至6年。为评估治疗效果，采用了听力学和前庭检查，包括宽频带旋转试验（0.4 - 4.5Hz）。14例患者治疗后眩晕消失。5例患者听力损失加重，10例患者听力无变化。耳鸣和胀满感减轻。治疗后，所有患耳对冷热试验均无反应。临床检查和正弦刺激下的旋转试验显示前庭功能丧失得到了良好的中枢代偿。然而，在黑暗中进行伪随机振荡时，宽频带旋转试验量化了外周前庭功能的丧失，并能够在9例患者中的8例中检测到病变侧。
