新型金属药物减轻非甾体抗炎药所致的肾损伤
New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory.
作者信息
Macêdo Clóvis Ney Pinheiro, Braga Francisco Evanilso Silva, Campelo Ana Paula Bomfim Soares, Diniz Gabriel Maia, Lopes Luiz Gonzaga de França, Kubrusly Marcos, Campelo Marcio Wilker Soares
机构信息
Fellow Master degree, Postgraduate Program in Minimally Invasive Technology and Health Simulation Area, Medical School, Centro Universitário Christus (UNICHRISTUS), Fortaleza-CE, Brazil. Conception and design of the study, technical procedures, acquisition and interpretation of data, manuscript preparation, critical revision.
Graduate student, Medical School, UNICHRISTUS, Fortaleza-CE, Brazil. Technical procedures, acquisition of data, manuscript preparation.
出版信息
Acta Cir Bras. 2020 Feb 3;34(12):e201901201. doi: 10.1590/s0102-865020190120000001. eCollection 2020.
PURPOSE
To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam).
METHODS
Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals.
RESULTS
At the histological examination, all animals (six animals - 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05).
CONCLUSION
Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
目的
评估新型一氧化氮供体Rut-bpy（顺式-[Ru(bpy)₂(SO₃)(NO)]PF₆）调节非甾体抗炎药（美洛昔康）所致组织学变化的效果。
方法
将Wistar大鼠分为三组（每组n = 6只大鼠）：假手术组（生理盐水）、非甾体抗炎药组（美洛昔康 - 15 mg/kg）和Rut-bpy组（100 mg/kg的Rut-bpy与15 mg/kg的美洛昔康联用）。实验结束时，取出所有动物的肾脏进行组织学研究、分形维数和孔隙率分析。
结果
组织学检查显示，非甾体抗炎药组所有动物（6只动物 - 100%）均出现膜增厚及其他变化（坏死、急性肾小管充血和血管充血）；另一方面，Rut-bpy组仅1只动物（16.6%）出现充血。对照组和Rut-bpy组的分形维数和孔隙率高于非甾体抗炎药组（p<0.05）。
结论
Rut-bpy可能预防美洛昔康所致大鼠肾脏组织学变化。
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