Santos Camila de Souza Dos, Bessa Thaíssa Araujo de, Xavier André Junqueira
Universidade Federal de Santa Catarina. R. Eng. Agrônomo Andrei Cristian Ferreira s/n, Trindade. 88040-900, Florianópolis, SC, Brasil.
Cien Saude Colet. 2020 Feb;25(2):603-611. doi: 10.1590/1413-81232020252.02042018. Epub 2018 May 18.
We analyzed the factors associated with dementia in the elderly attended at a memory outpatient clinic of the University of Southern Santa Catarina (UNISUL). This is a cross-sectional study with data analysis of medical records from January 2013 to April 2016. The outcome was the clinical diagnosis of dementia. The control variables were: serum vitamin D level at the time of diagnosis, gender, skin color, schooling, age, type 2 diabetes, hypertension, and depression. We performed a crude and adjusted analysis with logistic regression. The sample consisted of 287 elderly, with the predominance of age between 60 and 69 years (48.78%), female (79.09%) and white (92.33%). The mean number of years of study was 6.95 years (SD ± 4.95) and mean vitamin D was 26.09 ng/mL (SD ± 9,20). The prevalence of elderly with dementia was 16.72%. Depression was the most prevalent (42.50%) among the morbidities, followed by hypertension (31.71%). The following were independently associated with dementia: vitamin D (OR = 0.92, 95%CI, 0.88;0.97), depression (OR = 4.09, 95%CI, 1.87;8.94), hypertension (OR = 2.65, 95%CI, 1.15;6.08) and individuals aged 80 years and over (OR = 3.97 95%CI, 1.59;9.91). Dementia prevalence was high and diagnosed dementia was associated with lower levels of vitamin D. Vitamin D is a modifiable factor, opening up essential perspectives for public health policies.
我们分析了在南圣卡塔琳娜大学（UNISUL）记忆门诊就诊的老年人中与痴呆症相关的因素。这是一项横断面研究，对2013年1月至2016年4月的病历进行数据分析。研究结果为痴呆症的临床诊断。控制变量包括：诊断时的血清维生素D水平、性别、肤色、受教育程度、年龄、2型糖尿病、高血压和抑郁症。我们采用逻辑回归进行了粗分析和校正分析。样本包括287名老年人，年龄主要集中在60至69岁（48.78%），女性占多数（79.09%），白人占92.33%。平均受教育年限为6.95年（标准差±4.95），平均维生素D水平为26.09 ng/mL（标准差±9.20）。患有痴呆症的老年人患病率为16.72%。在各种疾病中，抑郁症最为普遍（42.50%），其次是高血压（31.71%）。以下因素与痴呆症独立相关：维生素D（比值比=0.92，95%置信区间，0.88；0.97）、抑郁症（比值比=4.09，95%置信区间，1.87；8.94）、高血压（比值比=2.65，95%置信区间，1.15；6.08）以及80岁及以上的个体（比值比=3.97，95%置信区间，1.59；9.91）。痴呆症患病率较高，且已诊断出的痴呆症与较低的维生素D水平相关。维生素D是一个可改变的因素，为公共卫生政策开辟了重要前景。
