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老年人痴呆相关因素。

Factors associated with dementia in elderly.

作者信息

Santos Camila de Souza Dos, Bessa Thaíssa Araujo de, Xavier André Junqueira

机构信息

Universidade Federal de Santa Catarina. R. Eng. Agrônomo Andrei Cristian Ferreira s/n, Trindade. 88040-900, Florianópolis, SC,  Brasil.

出版信息

Cien Saude Colet. 2020 Feb;25(2):603-611. doi: 10.1590/1413-81232020252.02042018. Epub 2018 May 18.

Abstract

We analyzed the factors associated with dementia in the elderly attended at a memory outpatient clinic of the University of Southern Santa Catarina (UNISUL). This is a cross-sectional study with data analysis of medical records from January 2013 to April 2016. The outcome was the clinical diagnosis of dementia. The control variables were: serum vitamin D level at the time of diagnosis, gender, skin color, schooling, age, type 2 diabetes, hypertension, and depression. We performed a crude and adjusted analysis with logistic regression. The sample consisted of 287 elderly, with the predominance of age between 60 and 69 years (48.78%), female (79.09%) and white (92.33%). The mean number of years of study was 6.95 years (SD ± 4.95) and mean vitamin D was 26.09 ng/mL (SD ± 9,20). The prevalence of elderly with dementia was 16.72%. Depression was the most prevalent (42.50%) among the morbidities, followed by hypertension (31.71%). The following were independently associated with dementia: vitamin D (OR = 0.92, 95%CI, 0.88;0.97), depression (OR = 4.09, 95%CI, 1.87;8.94), hypertension (OR = 2.65, 95%CI, 1.15;6.08) and individuals aged 80 years and over (OR = 3.97 95%CI, 1.59;9.91). Dementia prevalence was high and diagnosed dementia was associated with lower levels of vitamin D. Vitamin D is a modifiable factor, opening up essential perspectives for public health policies.

摘要

我们分析了在南圣卡塔琳娜大学(UNISUL)记忆门诊就诊的老年人中与痴呆症相关的因素。这是一项横断面研究,对2013年1月至2016年4月的病历进行数据分析。研究结果为痴呆症的临床诊断。控制变量包括:诊断时的血清维生素D水平、性别、肤色、受教育程度、年龄、2型糖尿病、高血压和抑郁症。我们采用逻辑回归进行了粗分析和校正分析。样本包括287名老年人,年龄主要集中在60至69岁(48.78%),女性占多数(79.09%),白人占92.33%。平均受教育年限为6.95年(标准差±4.95),平均维生素D水平为26.09 ng/mL(标准差±9.20)。患有痴呆症的老年人患病率为16.72%。在各种疾病中,抑郁症最为普遍(42.50%),其次是高血压(31.71%)。以下因素与痴呆症独立相关:维生素D(比值比=0.92,95%置信区间,0.88;0.97)、抑郁症(比值比=4.09,95%置信区间,1.87;8.94)、高血压(比值比=2.65,95%置信区间,1.15;6.08)以及80岁及以上的个体(比值比=3.97,95%置信区间,1.59;9.91)。痴呆症患病率较高,且已诊断出的痴呆症与较低的维生素D水平相关。维生素D是一个可改变的因素,为公共卫生政策开辟了重要前景。

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