Vasudeva Kanika, Munshi Anjana
Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, India.
Eur J Neurosci. 2020 Sep;52(6):3610-3627. doi: 10.1111/ejn.14695. Epub 2020 Feb 18.
Stroke is one of the leading causes of death and disability in both developing and developed countries. Biomarkers for stroke and its outcome can greatly facilitate early detection and management of the disease. miRNAs have been explored for their potential as biomarkers for diagnosis, prognosis and brain injury in ischaemic stroke. A substantial body of evidence suggests that miRNAs play key roles in numerous cellular changes following ischaemic stroke including mitochondrial dysfunction, energy failure, cytokine-mediated cytotoxicity, oxidative stress, activation of glial cells, increased intracellular calcium levels inflammatory responses and disruption of the blood-brain barrier (BBB). In addition, targeting specific miRNAs, therapeutic modulation of brain injury and apoptosis can also be achieved. Therefore, the current review has been compiled within an aim to give an overview of the developments exploiting miRNAs at different stages of stroke as prognostic, diagnostic, protective and therapeutic biomarkers.
中风是发展中国家和发达国家死亡和残疾的主要原因之一。中风及其预后的生物标志物可以极大地促进该疾病的早期检测和管理。人们已经探索了微小RNA（miRNAs）作为缺血性中风诊断、预后和脑损伤生物标志物的潜力。大量证据表明，miRNAs在缺血性中风后的众多细胞变化中起关键作用，包括线粒体功能障碍、能量衰竭、细胞因子介导的细胞毒性、氧化应激、胶质细胞激活、细胞内钙水平升高、炎症反应和血脑屏障（BBB）破坏。此外，通过靶向特定的miRNAs，还可以实现对脑损伤和细胞凋亡的治疗性调节。因此，本综述旨在概述在中风不同阶段将miRNAs用作预后、诊断、保护和治疗生物标志物的研究进展。
