Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Animal Disease Control Center of Haixi Mongolian and Tibetan Autonomous Prefecture, Delingha, Qinghai, China.
Anim Biotechnol. 2021 Aug;32(4):461-469. doi: 10.1080/10495398.2020.1719124. Epub 2020 Feb 5.
Copy number variation (CNV) as an important source of genetic phenotypic and variation is related to complex phenotypic traits. The aim of this study was to investigate the potential associations of copy numbers variations with sheep growth traits in three Chinese sheep breeds (CKS, STHS, and HS). is located within the stature and udder attachment quantitative trait loci (QTL) in sheep. Expression profiling revealed that the gene was widely expressed in the tissues of sheep. The distribution of gene copy number showed that the loss of copy number was more dominant in CKS and HS which was different from that in STHS. Statistical analysis revealed that the CNV was significantly associated with body height in CKS ( < 0.05), with body slanting length in HS ( < 0.05), and with body height and hip cross height in STHS ( < 0.05). The χ values showed significant differences in the CNV distribution frequency between varieties. In conclusion, the results establish the association between CNV and sheep traits and suggest that CNV may be a promising marker for the molecular breeding of Chinese sheep.
拷贝数变异 (CNV) 作为遗传表型和变异的重要来源，与复杂的表型特征有关。本研究旨在探讨中国三个绵羊品种（CKS、STHS 和 HS）中拷贝数变异与绵羊生长性状的潜在关联。位于绵羊体型和乳房附着数量性状基因座 (QTL) 内。表达谱分析表明，基因在绵羊组织中广泛表达。基因拷贝数的分布表明，CKS 和 HS 中拷贝数的缺失更为占主导地位，而 STHS 则不同。统计分析表明，CNV 与 CKS 的体高显著相关（<0.05），与 HS 的体斜长显著相关（<0.05），与 STHS 的体高和髋骨横径显著相关（<0.05）。 χ 值显示品种间 CNV 分布频率存在显著差异。总之，这些结果确立了 CNV 与绵羊性状之间的关联，并表明 CNV 可能是中国绵羊分子育种的有前途的标记。
