Price C D, Williams W J, Pugh A, Joynson D H
J Clin Pathol. 1977 Jan;30(1):24-28. doi: 10.1136/jcp.30.1.24.
The value of the beryllium macrophage migration inhibition (Be MIF) and Mantoux tests in the diagnosis of chronic beryllium disease and in the detection of hypersensitivity in healthy beryllium workers is demonstrated. In the absence of steroid treatment the Be MIF test is positive in chronic beryllium disease patients. Seven of 50 (14%) helathy beryllium workers were Be MIF positive, while all the control subjects, normal and sarcoidosis patients, were negative. Healthy beryllium workers tend to be more often Mantoux negative than a comparable group of non-exposed workers, and although not conclusive this finding correlates with a positive Be MIF test. Although the detection of hypersensitivity is not diagnostic of disease, the Be MIF test can be used as an additional method for monitoring the health of beryllium workers. The full significance of our results should be assessed by a long-term study.
证明了铍巨噬细胞移动抑制（Be MIF）试验和结核菌素试验在慢性铍病诊断以及健康铍作业工人超敏反应检测中的价值。在未接受类固醇治疗的情况下，慢性铍病患者的Be MIF试验呈阳性。50名健康铍作业工人中有7名（14%）Be MIF试验呈阳性，而所有对照对象，包括正常人和结节病患者，均为阴性。与未接触铍的可比工人组相比，健康铍作业工人结核菌素试验阴性的情况更为常见，尽管这一发现尚无定论，但与Be MIF试验阳性相关。虽然超敏反应的检测不能确诊疾病，但Be MIF试验可作为监测铍作业工人健康状况的一种辅助方法。我们研究结果的全部意义应通过长期研究来评估。
