Kim Woosung, Jang Yoonyoung, Lim Youn-Hee, Kim Bung-Nyun, Shin Choong Ho, Lee Young Ah, Kim Johanna Inhyang, Hong Yun-Chul
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea.
J Prev Med Public Health. 2020 Jan;53(1):29-36. doi: 10.3961/jpmph.19.175. Epub 2019 Nov 14.
Prenatal cadmium (Cd) exposure may be associated with attention-deficit/hyperactivity disorder (ADHD) in children. Therefore, the objective of this study was to examine the relationship between Cd exposure during gestation and ADHD at 6 years of age.
As part of an ongoing cohort study (the Environment and Development of Children study), 479 mother-child pairs from Seoul, Korea were included for analysis between 2008 and 2011. The whole blood concentration of Cd was analyzed using atomic absorption spectrophotometry. The parents were surveyed about ADHD behaviors in their children at age 6. Multivariable linear regression models were used to investigate the relationship between prenatal exposure to Cd and ADHD at 6 years of age.
Increased prenatal Cd concentrations were associated with increased scores for ADHD for girls, but not for boys, at age 6. A 2-fold increase in the prenatal Cd level was significantly associated with a 22.3% (95% confidence interval, 11.6 to 34.1) increase in ADHD in girls at 6 years of age, as indicated by the linear regression model.
Our results identified significant associations between prenatal Cd exposure and ADHD scores in 6-year-old girls.
产前镉（Cd）暴露可能与儿童注意力缺陷多动障碍（ADHD）有关。因此，本研究的目的是探讨孕期镉暴露与6岁儿童ADHD之间的关系。
作为一项正在进行的队列研究（儿童环境与发育研究）的一部分，2008年至2011年间纳入了来自韩国首尔的479对母婴进行分析。采用原子吸收分光光度法分析全血镉浓度。对父母进行调查，了解他们孩子6岁时的ADHD行为。使用多变量线性回归模型研究产前镉暴露与6岁儿童ADHD之间的关系。
产前镉浓度升高与6岁女孩的ADHD得分增加有关，但与男孩无关。线性回归模型显示，产前镉水平增加两倍与6岁女孩的ADHD显著增加22.3%（95%置信区间，11.6至34.1）相关。
我们的结果确定了产前镉暴露与6岁女孩的ADHD得分之间存在显著关联。
