Deschamps C, Rodarte J R
Division of Thoracic Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.
Am Rev Respir Dis. 1988 Jun;137(6):1385-9. doi: 10.1164/ajrccm/137.6.1385.
Lateral thoracotomy with pleural abrasion and application of talc was performed on 8 adult beagle dogs. The dogs had no effusion detectable on roentgenogram at the time of study, and obliteration of the pleural space was later confirmed by autopsy. With the dogs under pentobarbital anesthesia, lung mechanics and gas exchange were studied before and 5 wk after surgery. Total lung capacity decreased to 78% of control value (p less than 0.05). After the operation, pressure-volume curves of the respiratory system were shifted down, along with significantly decreased compliance. Maximal flow at constant lung volume was not significantly increased. Arterial O2 and CO2 tensions were not significantly different. Rebreathing DLCO normalized for lung volume was unchanged. The slope of phase III of a single-breath nitrogen test was increased (p less than 0.05) after surgery. Unilateral surgical obliteration of the pleural space results in a pure restrictive pattern. It does not affect the gas exchange surface. The increase in the slope of phase III is suggestive of a nonhomogeneous distribution of ventilation.
对8只成年比格犬进行了侧胸壁切开术，同时进行胸膜摩擦并应用滑石粉。在研究时，这些犬在X线片上未检测到胸腔积液，术后尸检证实胸膜腔闭塞。在戊巴比妥麻醉下，于手术前及术后5周对犬的肺力学和气体交换进行了研究。肺总量降至对照值的78%（p<0.05）。术后，呼吸系统的压力-容积曲线下移，顺应性显著降低。恒定肺容积下的最大流量未显著增加。动脉血氧分压和二氧化碳分压无显著差异。经肺容积标准化后的重复呼吸一氧化碳弥散量未改变。单次呼吸氮试验第三相的斜率在术后增加（p<0.05）。单侧手术闭塞胸膜腔导致单纯的限制性模式。它不影响气体交换表面。第三相斜率的增加提示通气分布不均一。
