St. Jude Childrens Cancer Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Department of Microbiology and Immunology, Institute for Biomedicine, Gothenburg University, 413 90 Gothenburg, Sweden.
Int J Mol Sci. 2020 Jan 31;21(3):961. doi: 10.3390/ijms21030961.
The clinical sampling of urine is noninvasive and unrestricted, whereby huge volumes can be easily obtained. This makes urine a valuable resource for the diagnoses of diseases. Urinary and renal proteomics have resulted in considerable progress in kidney-based disease diagnosis through biomarker discovery and treatment. This review summarizes the bioinformatics tools available for this area of proteomics and the milestones reached using these tools in clinical research. The scant research publications and the even more limited bioinformatic tool options available for urinary and renal proteomics are highlighted in this review. The need for more attention and input from bioinformaticians is highlighted, so that progressive achievements and releases can be made. With just a handful of existing tools for renal and urinary proteomic research available, this review identifies a gap worth targeting by protein chemists and bioinformaticians. The probable causes for the lack of enthusiasm in this area are also speculated upon in this review. This is the first review that consolidates the bioinformatics applications specifically for renal and urinary proteomics.
临床尿液采样具有非侵入性和无限制的特点，因此可以轻松获得大量尿液样本。这使得尿液成为疾病诊断的宝贵资源。尿液和肾脏蛋白质组学通过生物标志物的发现和治疗，在肾脏疾病诊断方面取得了相当大的进展。本综述总结了该蛋白质组学领域可用的生物信息学工具，以及使用这些工具在临床研究中取得的里程碑式进展。本综述强调了尿液和肾脏蛋白质组学研究中可用的研究出版物和生物信息学工具选择非常有限的问题。强调需要更多的生物信息学家的关注和投入，以取得不断的进展和发布。现有的用于肾脏和尿液蛋白质组学研究的工具寥寥无几，本综述确定了蛋白质化学家与生物信息学家值得关注的一个目标领域。本综述还推测了该领域缺乏积极性的可能原因。这是第一篇专门针对肾脏和尿液蛋白质组学的生物信息学应用综述。
