Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, Texas.
Physiology (Bethesda). 2020 Mar 1;35(2):86-95. doi: 10.1152/physiol.00034.2019.
In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol. By allowing the conversion of pyruvate to acetyl-CoA in mitochondria, melatonin reprograms glucose metabolism in cancer cells to a normal cell phenotype. Acetyl-CoA in the mitochondria also serves as a necessary co-factor for the rate-limiting enzyme in melatonin synthesis, thus ensuring melatonin production in mitochondria of normal cells.
在癌细胞中，葡萄糖主要在细胞质中代谢为丙酮酸，然后转化为乳酸。褪黑素使细胞质中的丙酮酸转化为乙酰辅酶 A，从而重新编程癌细胞中的葡萄糖代谢，使其向正常细胞表型转化。线粒体中的乙酰辅酶 A 也是褪黑素合成限速酶的必需辅助因子，从而确保正常细胞线粒体中褪黑素的生成。
