Yaghoobi Alireza, Rezaee Malihe, Hedayati Neda, Keshavarzmotamed Atoosa, Khalilzad Mohammad Amin, Russel Reitel, Asemi Zatollah, Rajabi Moghadam Hasan, Mafi Alireza
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Medicine, Iran University of Medical Science, Tehran, Iran.
Mol Cell Biochem. 2025 Feb;480(2):799-823. doi: 10.1007/s11010-024-05002-3. Epub 2024 Jul 9.
Cardiovascular diseases (CVDs) are the leading causes of death and illness worldwide. While there have been advancements in the treatment of CVDs using medication and medical procedures, these conventional methods have limited effectiveness in halting the progression of heart diseases to complete heart failure. However, in recent years, the hormone melatonin has shown promise as a protective agent for the heart. Melatonin, which is secreted by the pineal gland and regulates our sleep-wake cycle, plays a role in various biological processes including oxidative stress, mitochondrial function, and cell death. The Sirtuin (Sirt) family of proteins has gained attention for their involvement in many cellular functions related to heart health. It has been well established that melatonin activates the Sirt signaling pathways, leading to several beneficial effects on the heart. These include preserving mitochondrial function, reducing oxidative stress, decreasing inflammation, preventing cell death, and regulating autophagy in cardiac cells. Therefore, melatonin could play crucial roles in ameliorating various cardiovascular pathologies, such as sepsis, drug toxicity-induced myocardial injury, myocardial ischemia-reperfusion injury, hypertension, heart failure, and diabetic cardiomyopathy. These effects may be partly attributed to the modulation of different Sirt family members by melatonin. This review summarizes the existing body of literature highlighting the cardioprotective effects of melatonin, specifically the ones including modulation of Sirt signaling pathways. Also, we discuss the potential use of melatonin-Sirt interactions as a forthcoming therapeutic target for managing and preventing CVDs.
心血管疾病（CVDs）是全球死亡和疾病的主要原因。虽然在使用药物和医疗程序治疗心血管疾病方面取得了进展，但这些传统方法在阻止心脏病进展为完全心力衰竭方面的效果有限。然而，近年来，褪黑素这种激素已显示出有望成为心脏的保护剂。褪黑素由松果体分泌并调节我们的睡眠 - 觉醒周期，在包括氧化应激、线粒体功能和细胞死亡在内的各种生物过程中发挥作用。沉默调节蛋白（Sirt）家族的蛋白质因其参与许多与心脏健康相关的细胞功能而受到关注。已经充分证实，褪黑素激活Sirt信号通路，对心脏产生多种有益影响。这些影响包括维持线粒体功能、减少氧化应激、减轻炎症、防止细胞死亡以及调节心肌细胞的自噬。因此，褪黑素在改善各种心血管疾病（如败血症、药物毒性诱导的心肌损伤、心肌缺血 - 再灌注损伤、高血压、心力衰竭和糖尿病性心肌病）中可能发挥关键作用。这些作用可能部分归因于褪黑素对不同Sirt家族成员的调节。本综述总结了现有文献中突出褪黑素心脏保护作用的内容，特别是那些包括调节Sirt信号通路的作用。此外，我们讨论了褪黑素 - Sirt相互作用作为即将到来的治疗靶点用于管理和预防心血管疾病的潜在用途。
