Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium.
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium
J Virol. 2020 Mar 31;94(8). doi: 10.1128/JVI.02120-19.
Tunneling nanotubes (TNTs) are actin-based intercellular conduits that connect distant cells and allow intercellular transfer of molecular information, including genetic information, proteins, lipids, and even organelles. Besides providing a means of intercellular communication, TNTs may also be hijacked by pathogens, particularly viruses, to facilitate their spread. Viruses of many different families, including retroviruses, herpesviruses, orthomyxoviruses, and several others have been reported to trigger the formation of TNTs or TNT-like structures in infected cells and use these structures to efficiently spread to uninfected cells. In the current review, we give an overview of the information that is currently available on viruses and TNT-like structures, and we discuss some of the standing questions in this field.
隧道纳米管（TNTs）是基于肌动蛋白的细胞间通道，可连接远距离细胞，并允许分子信息（包括遗传信息、蛋白质、脂质，甚至细胞器）在细胞间转移。除了提供细胞间通讯的一种手段外，TNTs 还可能被病原体（特别是病毒）劫持，以促进其传播。许多不同家族的病毒，包括逆转录病毒、疱疹病毒、正粘病毒和其他几种病毒，据报道可触发感染细胞中 TNTs 或 TNT 样结构的形成，并利用这些结构有效地传播到未感染的细胞。在当前的综述中，我们概述了目前关于病毒和 TNT 样结构的信息，并讨论了该领域的一些悬而未决的问题。
