Butler 可实现数千个人类基因组的快速基于云的分析。
Butler enables rapid cloud-based analysis of thousands of human genomes.
机构信息
European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Institute of Computer Science, Heidelberg University, Heidelberg, Germany.
出版信息
Nat Biotechnol. 2020 Mar;38(3):288-292. doi: 10.1038/s41587-019-0360-3. Epub 2020 Feb 5.
We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.
我们介绍 Butler，这是一个计算工具，可在公共云和学术云上进行大规模基因组分析。Butler 包括创新的异常检测和自我修复功能，与当前方法相比，可将数据处理和分析的效率提高 43%。Butler 以高效和统一的方式处理了来自 Pan-Cancer Analysis of Whole Genomes (PCAWG) 项目的 725 太字节癌症基因组数据集。
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