Cheung Zoe B, Anthony Shawn G, Forsh David A, Podolnick Jeremy, Zubizarreta Nicole, Galatz Leesa M, Poeran Jashvant
Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA.
Institute for Healthcare Delivery Science, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA.
J Orthop. 2020 Jan 28;20:167-172. doi: 10.1016/j.jor.2020.01.040. eCollection 2020 Jul-Aug.
To assess the effect of tranexamic acid (TXA) use in hip fracture surgery.
A retrospective cohort study was performed using the Premier Healthcare database. A propensity score matching approach was applied to assess associations between TXA use and blood transfusion, perioperative complications, length of stay (LOS), and hospitalization cost.
In 153,169 patients, TXA use was associated with a 17% decrease in odds of blood transfusion, no increase in the risk of perioperative complications, 16% shorter LOS, and minimal effects on hospitalization cost.
Our results are in support of a wider use of TXA in hip fracture surgery.
Level III.
评估氨甲环酸（TXA）在髋部骨折手术中的应用效果。
利用Premier医疗数据库进行一项回顾性队列研究。采用倾向评分匹配法评估TXA使用与输血、围手术期并发症、住院时间（LOS）和住院费用之间的关联。
在153169例患者中，使用TXA与输血几率降低17%、围手术期并发症风险未增加、住院时间缩短16%以及对住院费用影响极小相关。
我们的结果支持在髋部骨折手术中更广泛地使用TXA。
三级。
