Nayak Mayur, Kumar Vijay, Kanojiya Gourav, Mellon Stephen, Srivastava Deep Narayan, Pandit Hemant, Malhotra Rajesh
Department of Orthopedics, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
Botnar Research Centre, University of Oxford, Oxford, UK.
J Orthop. 2019 Dec 17;20:207-212. doi: 10.1016/j.jor.2019.12.003. eCollection 2020 Jul-Aug.
This study aimed to investigate the alignment based on deformity in knees affected by osteoarthritis (OA) at different stages and evaluate its association with OA.
The following radiological parameters were measured from weight bearing long leg radiographs of 966 legs in the Indian subjects via a morphometric software (Matlab R2009a) (1)Hip-Knee-Ankle angle (HKAA), (2) Femoral bowing, (3) Tibial Bowing, (4) Condylar Plateau angle (CPA). The knees were classified according to the Kellegren and Lawrence grading and these parameters were evaluated with OA for its association using appropriate statistical tests.
The mean HKAA angle was 174.5° ±6.5°, 65.8% of the limbs were in found to be in varus (<177°) and 3.8% in valgus (>183°). The mean femoral and tibial bowing was -1.19 ± 4.95° and -1.54 ± 3.58° respectively. 55.8% of femorae and 41.4% of the tibia were observed to have varus bowing while 24.12% of femorae and 12.11% the tibia were observed to have valgus bowing. An increase in odds of disease severity was observed with femoral and tibial bowing >2°. With an increase in the grades of OA a significant increase in the lateral bow of both femur and tibia was observed. The mean condylar plateau angle was observed to be -2.53° ±7.9°. Positive association was seen between the varus CPA, HKA and OA (p ).
This study describes the various radiological parameters in Indian patients at different grades of OA and might elucidate the role of these factors in OA initiation and progression.
本研究旨在调查不同阶段骨关节炎（OA）患者膝关节基于畸形的对线情况，并评估其与OA的相关性。
通过形态测量软件（Matlab R2009a），从966例印度受试者负重长腿X线片测量以下放射学参数：（1）髋-膝-踝角（HKAA），（2）股骨弯曲度，（3）胫骨弯曲度，（4）髁间平台角（CPA）。根据Kellegren和Lawrence分级对膝关节进行分类，并使用适当的统计检验评估这些参数与OA的相关性。
HKAA平均角度为174.5°±6.5°，65.8%的肢体呈内翻（<177°），3.8%呈外翻（>183°）。股骨和胫骨的平均弯曲度分别为-1.19±4.95°和-1.54±3.58°。观察到55.8%的股骨和41.4%的胫骨有内翻弯曲，而24.12%的股骨和12.11%的胫骨有外翻弯曲。股骨和胫骨弯曲>2°时，疾病严重程度的几率增加。随着OA等级的增加，观察到股骨和胫骨的外侧弯曲均显著增加。髁间平台角平均为-2.53°±7.9°。内翻CPA、HKA与OA之间存在正相关（p值）。
本研究描述了不同OA等级印度患者的各种放射学参数，并可能阐明这些因素在OA发生和发展中的作用。
