Venge P, Dahl R, Fredens K, Peterson C G
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
Am Rev Respir Dis. 1988 Dec;138(6 Pt 2):S54-7. doi: 10.1164/ajrccm/138.6_Pt_2.S54.
The human eosinophil is armed with a number of very potent cytotoxic granule proteins that upon extracellular release may produce considerable damage. The toxic effect of the proteins seems to be quite unselective, involving most mammalian and nonmammalian cells including the epithelial cells. The demonstration of a close relation between the deposition of eosinophil granule proteins and areas of epithelial cell destruction in a variety of diseases including asthma and the fact that cytotoxic concentrations of the proteins have been measured in the fluid phase suggest that the eosinophil participates actively in the pathogenesis of airway diseases. The protection towards the adverse actions of the eosinophil, particularly towards their proteins, therefore seems vital. The discovery of alpha-2-macroglobulin as a specific binder of eosinophil cationic protein may be relevant in this regard.
人类嗜酸性粒细胞含有多种非常强效的细胞毒性颗粒蛋白，这些蛋白在细胞外释放时可能会造成相当大的损害。这些蛋白的毒性作用似乎相当无选择性，涉及大多数哺乳动物和非哺乳动物细胞，包括上皮细胞。在包括哮喘在内的多种疾病中，嗜酸性粒细胞颗粒蛋白的沉积与上皮细胞破坏区域之间存在密切关系，并且在液相中已检测到这些蛋白的细胞毒性浓度，这表明嗜酸性粒细胞积极参与气道疾病的发病机制。因此，对嗜酸性粒细胞的不良作用，尤其是对其蛋白的保护似乎至关重要。在这方面，α-2-巨球蛋白作为嗜酸性粒细胞阳离子蛋白的特异性结合剂的发现可能具有相关性。
