Chihara J, Yamamoto T, Kurachi D, Kakazu T, Higashimoto I, Nakajima S
Fourth Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
Int Arch Allergy Immunol. 1995;108 Suppl 1:52-4. doi: 10.1159/000237204.
The presence of a large variety of membrane receptors and the identification of cytotoxic molecules (mainly granule basic proteins) have indicated that eosinophils should br considered as effector cells. It has recently been suggested that adhesion molecules, particularly intercellular adhesion molecule-1 (ICAM-1), play an important role in allergic inflammation, for example in bronchial asthma. This study therefore investigated the possible release of granule protein in response to signaling from ICAM-1 and its ligands. The concentrations of eosinophil cationic protein and eosinophil-derived neurotoxin in supernatants of eosinophils were significantly greater (p < 0.05) in the presence of recombinant soluble ICAM-1 than without it. These results suggest that signaling from ICAM-1 and its ligands might induce eosinophil activation and might be involved in degranulation of eosinophil granule proteins, e.g. eosinophil cationic protein and eosinophil-derived neurotoxin.
多种膜受体的存在以及细胞毒性分子（主要是颗粒碱性蛋白）的鉴定表明，嗜酸性粒细胞应被视为效应细胞。最近有人提出，黏附分子，特别是细胞间黏附分子-1（ICAM-1），在过敏性炎症中起重要作用，例如在支气管哮喘中。因此，本研究调查了嗜酸性粒细胞可能因ICAM-1及其配体的信号传导而释放颗粒蛋白的情况。在存在重组可溶性ICAM-1的情况下，嗜酸性粒细胞上清液中嗜酸性粒细胞阳离子蛋白和嗜酸性粒细胞衍生神经毒素的浓度显著更高（p < 0.05）。这些结果表明，ICAM-1及其配体的信号传导可能诱导嗜酸性粒细胞活化，并可能参与嗜酸性粒细胞颗粒蛋白（如嗜酸性粒细胞阳离子蛋白和嗜酸性粒细胞衍生神经毒素）的脱颗粒过程。
