Alyautdina Olga S, Esina Elena V
Department of Obstetrics and Gynecology, Sechenov First Moscow State Medical University, Moscow, Russian Federation.
MedSwiss Medical Center, Moscow, Russian Federation.
J Med Life. 2019 Oct-Dec;12(4):368-373. doi: 10.25122/jml-2019-0068.
Traditional therapy and extensive use of medications and intravaginal autolymphocyte therapy show different results of the treatment of vulvovaginal infections. The purpose of the article was to explore safe and highly effective methods to treat vulvovaginal infections and diseases of the pelvic organs. The standard clinical and laboratory screening of 70 patients of reproductive age was carried out to diagnose the diseases of the reproductive tract. The screening included the description of quantitative and qualitative characteristics of vaginal discharge, examining the mucous covering of the vulva and vagina, microscopic examination of Gram-stained vaginal swabs, endocervical cultures, and diagnosis of sexually transmitted infections using polymerase chain reaction. Intravaginal autolymphocyte therapy was used together with traditionally-accepted treatment schemes (etiotropic antibacterial and antifungal therapy) in the treatment of the main group (40 patients). Traditional treatment methods depending on the etiology of the development of infection were used in the control group (30 patients). The IgM, IgA, and IgG levels were also observed because of the possibility of causing embryo rejection. This study shows that in case of relapsing vulvovaginitis and mixed infections accompanied by disorders of the immune system at different levels, the use of intravaginal autolymphocyte therapy in a comprehensive therapy can be assessed as advisable and pathogenetically substantiated.
传统疗法、大量使用药物以及阴道内自体淋巴细胞疗法在治疗外阴阴道感染方面显示出不同的治疗效果。本文的目的是探索治疗外阴阴道感染和盆腔器官疾病的安全且高效的方法。对70名育龄患者进行了标准的临床和实验室筛查，以诊断生殖道疾病。筛查包括描述阴道分泌物的定量和定性特征、检查外阴和阴道的黏膜覆盖情况、对革兰氏染色的阴道拭子进行显微镜检查、宫颈管培养以及使用聚合酶链反应诊断性传播感染。在主要治疗组（40名患者）的治疗中，阴道内自体淋巴细胞疗法与传统认可的治疗方案（病因特异性抗菌和抗真菌疗法）联合使用。对照组（30名患者）采用了根据感染发生病因而定的传统治疗方法。由于存在导致胚胎排斥的可能性，还观察了IgM、IgA和IgG水平。这项研究表明，在复发性外阴阴道炎和伴有不同程度免疫系统紊乱的混合感染的情况下，在综合治疗中使用阴道内自体淋巴细胞疗法可被认为是可取的且有病理依据的。
