Ren Jianhan, Huang Delan, Li Runze, Wang Weicai, Zhou Chen
Guanghua School of Stomatology, Hospital of Stomatology, and Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, 56 Lingyuanxi Road, Guangzhou, 510055 China.
Cell Biosci. 2020 Feb 3;10:11. doi: 10.1186/s13578-020-0378-8. eCollection 2020.
Mesenchymal stem cells (MSCs) are considered the most promising seed cells for regenerative medicine because of their considerable therapeutic properties and accessibility. Fine-tuning of cell biological processes, including differentiation and senescence, is essential for achievement of the expected regenerative efficacy. Researchers have recently made great advances in understanding the spatiotemporal gene expression dynamics that occur during osteogenic, adipogenic and chondrogenic differentiation of MSCs and the intrinsic and environmental factors that affect these processes. In this context, histone modifications have been intensively studied in recent years and have already been indicated to play significant and universal roles in MSC fate determination and differentiation. In this review, we summarize recent discoveries regarding the effects of histone modifications on MSC biology. Moreover, we also provide our insights and perspectives for future applications.
间充质干细胞（MSCs）因其具有相当大的治疗特性和易获取性，被认为是再生医学中最有前景的种子细胞。对包括分化和衰老在内的细胞生物学过程进行微调，对于实现预期的再生效果至关重要。近年来，研究人员在理解间充质干细胞成骨、成脂和成软骨分化过程中发生的时空基因表达动态以及影响这些过程的内在和环境因素方面取得了巨大进展。在这种背景下，组蛋白修饰近年来受到了深入研究，并且已经表明在间充质干细胞命运决定和分化中发挥着重要且普遍的作用。在这篇综述中，我们总结了关于组蛋白修饰对间充质干细胞生物学影响的最新发现。此外，我们还为未来的应用提供了见解和观点。
