功能化核壳氧化钇纳米粒子作为热应激大鼠的抗氧化剂。
Functionalized Core-Shell Yttrium Oxide Nanoparticles as Antioxidants Agents in Heat Stressed Rats.
机构信息
Department of Biotechnology, Animal Health Research Institute, Giza, 12618, Egypt.
Department of Animal Medicine, Faculty of Veterinary Medicine, University of Kafr El-Sheikh, Kafr El-Sheikh, Egypt.
出版信息
Biol Trace Elem Res. 2020 Nov;198(1):189-197. doi: 10.1007/s12011-020-02036-8. Epub 2020 Feb 5.
Herein, we assess the antioxidant potential of core-shell yttrium oxide nanoparticles functionalized with ethylene glycol methacrylate phosphate (EGMP). The antioxidant properties of these nanoparticles were investigated in heat stressed models of 21 rats (heat stressed group, group B). Different samples of blood, serum, and tissue homogenate were collected at different time intervals in order to measure oxidative biomarkers such as enzymatic antioxidants (SODs, GPX, GST, GR, and TAC) and oxidative byproducts (MDA, PC, and 8-OHdG). Liver specimens of prophylactic group and heat stressed ones were also histopathologically examined 2 h post NPs injection. The measurements of oxidative biomarkers were complementary with histopathological findings and confirmed the antioxidant properties of poly EGMP yttrium oxide NPs.
在此，我们评估了用甲基丙烯酸乙二醇磷酸酯（EGMP）功能化的核壳氧化钇纳米粒子的抗氧化潜力。我们在 21 只热应激大鼠模型（热应激组，B 组）中研究了这些纳米粒子的抗氧化特性。在不同的时间间隔收集不同的血液、血清和组织匀浆样本，以测量氧化生物标志物，如酶抗氧化剂（SOD、GPX、GST、GR 和 TAC）和氧化副产物（MDA、PC 和 8-OHdG）。预防性组和热应激组的肝组织标本也在 NPs 注射后 2 小时进行了组织病理学检查。氧化生物标志物的测量结果与组织病理学发现相辅相成，证实了多 EGMP 氧化钇纳米粒子的抗氧化特性。
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