Department of Medical Engineering, Global Center for Hearing & Speech Research, University of South Florida, Tampa, FL, USA.
Department of Chemical & Biological Engineering, Global Center for Hearing & Speech Research, University of South Florida, Tampa, FL, USA.
J Neurosci Res. 2020 Sep;98(9):1721-1730. doi: 10.1002/jnr.24588. Epub 2020 Feb 5.
Hormones such as estrogen, progesterone, and aldosterone all demonstrate vital roles in sustaining auditory function through either the maintenance of cochlear neurons, up/down regulation of critical molecules (i.e., IGF-1, BDNF, etc.), or generation of the endocochlear potential. With disease and/or age, hormone expression begins to decline drastically, which ultimately affects cochlear structures and the integrity of cochlear cells. The following review explores the latest findings as well as realistic outcomes for hormone therapy treatment in the auditory system. This information could serve as a potential guide for patients considering hormone therapy as a medicinal choice to alleviate the signs of onset of presbycusis-age-related hearing loss. Additional scientific investigations could also be carried out to further enhance recent findings.
激素如雌激素、孕激素和醛固酮都通过维持耳蜗神经元、调节关键分子（如 IGF-1、BDNF 等）的上下调控，或产生内淋巴电位，在维持听觉功能方面发挥着重要作用。随着疾病和/或年龄的增长，激素表达开始急剧下降，这最终会影响耳蜗结构和耳蜗细胞的完整性。以下综述探讨了激素治疗在听觉系统中的最新发现和实际结果。这些信息可以为考虑激素治疗作为缓解老年聋（与年龄相关的听力损失）发病迹象的药物选择的患者提供潜在指导。还可以进行更多的科学研究来进一步加强最近的发现。
