School of Psychology, Shandong Normal University, Jinan, China.
Department of Computer Science, National University of Ireland, Dublin, Ireland.
Scand J Psychol. 2020 Oct;61(5):634-641. doi: 10.1111/sjop.12620. Epub 2020 Feb 6.
We investigated the role of inhibition failure in Obsessive Compulsive Disorder (OCD) through an eye tracking experiment. Twenty-five subjects with OCD were recruited, as well as 25 with Generalized Anxiety Disorder (GAD) and 25 healthy controls. A 3 (group: OCD group, GAD group and control group) × 2 (target eccentricity: far and near) × 2 (saccade task: prosaccade and antisaccade) mixed design was used, with all participants completing two sets of tasks involving both prosaccade (eye movement towards a target) and antisaccade (eye movement away from a target). The main outcome was the eye movement index, including the saccade latency (the time interval from the onset of the target screen to the first saccade) and the error rate of saccade direction. The antisaccade latency and antisaccade error rates for OCDs were much higher than those for GADs and healthy controls. OCDs had longer latency and error rates for antisaccades than for prosaccades, and for far-eccentricity rather than near-eccentricity stimuli. These results suggest that OCDs experience difficulty with behavior inhibition, and that they have higher visual sensitivity to peripheral stimuli. In particular, they show greatest difficulty in inhibiting behavior directed towards peripheral stimuli.
我们通过眼动实验研究了抑制失败在强迫症（OCD）中的作用。招募了 25 名 OCD 患者、25 名广泛性焦虑症（GAD）患者和 25 名健康对照者。采用 3（组：OCD 组、GAD 组和对照组）×2（目标偏心率：远和近）×2（扫视任务：正扫视和反扫视）混合设计，所有参与者都完成了两组涉及正扫视（眼睛向目标移动）和反扫视（眼睛从目标移动）的任务。主要结果是眼动指标，包括扫视潜伏期（从目标屏幕出现到第一次扫视的时间间隔）和扫视方向的错误率。与 GAD 患者和健康对照组相比，OCD 患者的反扫视潜伏期和反扫视错误率明显更高。OCD 患者的反扫视潜伏期和错误率比正扫视长，对外周刺激的远偏心率比近偏心率更敏感。这些结果表明，OCD 患者存在行为抑制困难，对周围刺激的视觉敏感性更高。特别是，他们在抑制对外周刺激的行为方面存在最大困难。
