Dept. of Child & Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore Hosur Road, Bangalore, Pin: 560029; Department of Psychiatry, Institute of Post Graduate Medical Education & Research, 7 D. L. Khan Road, Kolkata, West Bengal.
Translational Psychiatry Lab, Department of Psychiartry, National Institute of Mental Health and Neurosciences, Bangalore Hosur Road, Bangalore, Pin: 560029.
Asian J Psychiatr. 2019 Jun;43:9-16. doi: 10.1016/j.ajp.2019.04.003. Epub 2019 Apr 24.
Till date researchers have elucidated the neurobiological substrates in OCD using methods like neuroimaging. However, a potential biomarker is still elusive. The present study is an attempt to identify a potential biomarker in pediatric OCD using eye tracking. The present study measured pro-saccade and anti-saccade parameters in 36 cases of pediatric OCD and 31 healthy controls. There was no significant difference between cases and controls in the error rate, peak velocity, position gain and latency measures in both pro-saccade and anti-saccade eye tracking tasks. With age, anti-saccades become slower in velocity, faster in response and more accurate irrespective of disorder status of the child. Pro-saccades also show a similar effect that is less prominent than anti-saccades. Gain measures more significantly vary with age in children with OCD than the controls, whereas latency measures positively correlated with age in children with OCD as opposed to being negatively correlated in the controls. Findings of this study do not support any of the eye tracking measures as putative diagnostic bio-markers in OCD. However, latency and gain parameters across different age groups in anti-saccade tasks need to be explored in future studies.
迄今为止，研究人员已经使用神经影像学等方法阐明了强迫症的神经生物学基础。然而，潜在的生物标志物仍然难以捉摸。本研究试图使用眼动追踪技术在儿科强迫症中识别潜在的生物标志物。本研究测量了 36 例儿科强迫症患者和 31 名健康对照者的前瞻性和反跳性眼球追踪参数。在前瞻性和反跳性眼球追踪任务中，病例组和对照组在错误率、峰值速度、位置增益和潜伏期测量方面均无显著差异。随着年龄的增长，反跳性眼球运动的速度会变慢，反应速度会变快，准确性会提高，而与儿童的疾病状态无关。前瞻性眼球运动也表现出类似的效应，但不如反跳性眼球运动明显。与对照组相比，强迫症儿童的增益测量值随年龄变化更为显著，而与对照组相反，强迫症儿童的潜伏期测量值与年龄呈正相关。本研究的结果不支持任何一种眼球追踪测量作为强迫症的潜在诊断生物标志物。然而，需要在未来的研究中探索不同年龄组反跳性眼球运动任务中的潜伏期和增益参数。
