Periodontology Unit, UCL Eastman Dental Institute and NIHR UCLH Biomedical Research Centre, University College London, London, UK.
Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain.
J Clin Periodontol. 2020 May;47(5):561-571. doi: 10.1111/jcpe.13267. Epub 2020 Mar 12.
To investigate whether periodontitis is associated with amyloid beta (Aβ) peptides and whether systemic inflammation could act as a potential mediator of this link.
A case-control study was designed including 75 patients with periodontitis (cases) and 75 age-balanced and gender-matched participants without periodontitis (controls). Full-mouth periodontal evaluation was performed in all participants. Demographic, clinical and behaviour data were also recorded. Fasting blood samples were collected, and serum levels of interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), Aβ and Aβ were determined.
Cases showed higher levels of IL-6 (8.7 ± 3.2 vs. 4.8 ± 0.5 pg/ml), hs-CRP (3.3 ± 1.2 vs. 0.9 ± 0.7 mg/L), Aβ (37.3 ± 6.0 vs. 30.3 ± 1.8 pg/ml) and Aβ (54.5 ± 10.6 vs. 36.5 ± 10.0 pg/ml) when compared to controls (all p < .001). Diagnosis of periodontitis was statistically significantly associated with circulating Aβ ( = 6.9, 95% CI: 5.4-8.3; p < .001) and Aβ ( = 17.8, 95% CI: 14.4-21.3; p < .001). Mediation analysis confirmed hs-CRP and IL-6 as mediators of this association.
Periodontitis is associated with increased peripheral levels of Aβ. This finding could be explained by enhanced systemic inflammation that can be seen in patients with periodontitis.
探讨牙周炎是否与淀粉样β（Aβ）肽有关，以及全身炎症是否可能作为这种联系的潜在介质。
设计了一项病例对照研究，纳入 75 例牙周炎患者（病例组）和 75 例年龄匹配、性别匹配且无牙周炎的参与者（对照组）。所有参与者均进行全口牙周评估。还记录了人口统计学、临床和行为数据。采集空腹血样，测定血清白细胞介素 6（IL-6）、高敏 C 反应蛋白（hs-CRP）、Aβ 和 Aβ水平。
与对照组相比，病例组的 IL-6（8.7 ± 3.2 比 4.8 ± 0.5 pg/ml）、hs-CRP（3.3 ± 1.2 比 0.9 ± 0.7 mg/L）、Aβ（37.3 ± 6.0 比 30.3 ± 1.8 pg/ml）和 Aβ（54.5 ± 10.6 比 36.5 ± 10.0 pg/ml）水平更高（均 p <.001）。牙周炎的诊断与循环 Aβ（ = 6.9，95%CI：5.4-8.3；p <.001）和 Aβ（ = 17.8，95%CI：14.4-21.3；p <.001）呈统计学显著相关。中介分析证实 hs-CRP 和 IL-6 是这种关联的中介物。
牙周炎与外周 Aβ水平升高有关。这种发现可以用牙周炎患者中增强的全身炎症来解释。
