Kaliamoorthy Sriram, Nagarajan Mahendirakumar, Sethuraman Vijayparthiban, Jayavel Kavitha, Lakshmanan Vijayalakshmi, Palla Santosh
Department of Dentistry, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation, (Deemed to be University), Karaikal, Puducherry, India.
Department of Prosthodontics, and Crown & Bridge, Raja Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India.
Med Pharm Rep. 2022 Apr;95(2):144-151. doi: 10.15386/mpr-2278. Epub 2022 Apr 28.
The relationship between periodontitis (or periodontal disease) with Alzheimer's disease has been reported by various primary sources in the past decade, but not with a solid secondary research statement. A systematic review and meta-analysis was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and registered (Reference number: CRD42020185264) with PROSPERO (International prospective register for systematic reviews). A literature search was conducted on specific databases for suitable articles in English language. Out of 612 studies selected, 41 underwent full-text analysis; five studies were eligible for systematic review, and 3 for meta-analysis. Meta-analysis was performed with tests for sensitivity and statistical heterogeneity followed by calculation of summary effect measures in terms of odds ratio (OR) and 95% confidence interval (CI). The results of this review showed a significant association between periodontitis and Alzheimer's disease in the meta-analysis [OR 1.67 (1.21-2.32)].
在过去十年中，各种主要资料来源都报道了牙周炎（或牙周病）与阿尔茨海默病之间的关系，但尚无确凿的二次研究报告。本研究按照系统评价和Meta分析的首选报告项目（PRISMA）声明的指南进行了一项系统评价和Meta分析，并在国际前瞻性系统评价注册库PROSPERO上进行了注册（注册号：CRD42020185264）。在特定数据库中进行文献检索，以查找合适的英文文章。在筛选出的612项研究中，41项进行了全文分析；5项研究符合系统评价的条件，3项符合Meta分析的条件。进行Meta分析时，先进行敏感性检验和统计异质性检验，然后计算比值比（OR）和95%置信区间（CI）的汇总效应量。本评价结果显示，在Meta分析中，牙周炎与阿尔茨海默病之间存在显著关联[OR 1.67（1.21-2.32）]。
