Handlinger J H, Williams W
NSW Department of Agriculture, Veterinary Research Station, Glenfield, Australia.
Avian Dis. 1988 Oct-Dec;32(4):773-8.
A new disease in broiler breeders known in Australia as Big Liver and Spleen Disease (BLS) is described from field observations, retrospective record analysis, and detailed study of a selected flock. BLS has a predilection for adult birds. It is characterized clinically by a sudden drop in egg production, splenomegaly, hepatomegaly, and increased mortality and histologically by a period of lymphoproliferation followed by a period of lymphoid destruction that coincides with the clinical signs. Epidemiology suggests an infectious cause, though initial attempts at isolation of a causative agent have been unsuccessful, and it is serologically distinct from the common avian viral and mycoplasma diseases.
通过实地观察、回顾性记录分析以及对选定鸡群的详细研究，描述了一种在澳大利亚肉鸡种鸡中出现的新疾病，称为大肝脾病（BLS）。BLS易发生于成年鸡。其临床特征为产蛋量突然下降、脾肿大、肝肿大以及死亡率增加，组织学特征为一段淋巴增殖期，随后是一段与临床症状相符的淋巴组织破坏期。流行病学研究表明这是一种传染性病因，尽管最初分离病原体的尝试未成功，并且在血清学上它与常见的禽类病毒和支原体疾病不同。
