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成年和幼年山羊中低温保存下颌髁突的移植

Transplantation of cryogenically preserved mandibular condyles in the adult and juvenile goat.

作者信息

Bifano C A, Grellner T, Houston G, Farr S C, Ehler W J, Cissik J H, Chastain M

机构信息

Directorate of Dental Services, Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas 78236-5300.

出版信息

Aviat Space Environ Med. 1988 Nov;59(11 Pt 2):A76-80.

PMID:3202807
Abstract

Loss of a functional temporomandibular joint (TMJ), due to various causes including tumor resection, joint disease such as osteonecrosis, and injury or trauma, has long been a clinical challenge in both children and adults. It may be a significant problem facing physicians during another war. While reconstruction to date has been performed with various prosthetic devices or autogenous costochondral grafts, these procedures have a potential for complications and morbidity. This procedure could adversely delay the return of military members to a combat unit, or affect their ability to serve as functional members of society. Our studies were performed to determine the feasibility of TMJ reconstruction techniques, healing, and long-term function and growth using cryogenically preserved mandibular allografts in the goat. This species was chosen because the surgical anatomy and biomechanics of the goat TMJ are very similar to that of the human. The positive results of the studies and their relevance to future military medical readiness and civilian medicine will be described.

摘要

由于包括肿瘤切除、骨坏死等关节疾病以及损伤或创伤等多种原因导致的功能性颞下颌关节(TMJ)丧失,长期以来一直是儿童和成人面临的临床挑战。这可能是另一场战争期间医生面临的重大问题。虽然迄今为止已经使用各种假体装置或自体肋软骨移植进行了重建,但这些手术存在并发症和发病的可能性。此手术可能会不利地延迟军人返回作战部队,或影响他们作为社会功能成员的服务能力。我们进行这些研究是为了确定在山羊中使用低温保存的下颌骨同种异体移植物进行颞下颌关节重建技术、愈合以及长期功能和生长的可行性。选择该物种是因为山羊颞下颌关节的手术解剖结构和生物力学与人的非常相似。将描述研究的积极结果及其与未来军事医疗准备和民用医学的相关性。

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