Bifano C A, Hubbard G, Ehler W J
Oral/Maxillofacial Surgery, Wilford Hall Medical Center, Lackland AFB Tex.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Sep;80(3):267-72. doi: 10.1016/s1079-2104(05)80381-6.
The purpose of this study was to determine the feasibility of total temporomandibular joint reconstruction with the use of cryogenically preserved allograft mandibular condyle, disk, and fossa in the adult goat.
This study consisted of an experimental group of 10 adult goats that underwent total resection of their temporomandibular joints. These animals were immediately reconstructed with cryogenically preserved mandibular condyles, disks, and fossa. These allograft were harvested from 10 donor animals matched to the recipient animal with respect to age, sex, and head dimensions. These grafts were harvested and stored at -185 degrees C for several months before implantation. At 2 years after surgery, the animals were killed. They were evaluated, clinically, radiographically, and histologically.
Fifty percent of the eight surviving animals had a normal clinically functional joint with an intact superior joint space and viable articular surfaces.
The authors conclude that this temporomandibular joint reconstruction technique is feasible in the adult goat model and is deserving of further research.
本研究的目的是确定在成年山羊中使用低温保存的同种异体下颌骨髁突、关节盘和关节窝进行全颞下颌关节重建的可行性。
本研究包括一个实验组，由10只成年山羊组成，这些山羊接受了颞下颌关节的全切除。这些动物立即用低温保存的下颌骨髁突、关节盘和关节窝进行重建。这些同种异体移植物取自10只供体动物，在年龄、性别和头部尺寸方面与受体动物相匹配。这些移植物在植入前被采集并在-185摄氏度下储存数月。术后2年，处死动物。对它们进行临床、放射学和组织学评估。
八只存活动物中有50%具有正常的临床功能关节，关节上间隙完整，关节表面存活。
作者得出结论，这种颞下颌关节重建技术在成年山羊模型中是可行的，值得进一步研究。
