Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 71-460 Szczecin, Poland.
Liver and Internal Medicine Unit. Department of General. Transplant and Liver Surgery of the Medical University of Warsaw, 02-097 Warsaw, Poland.
Medicina (Kaunas). 2020 Feb 3;56(2):58. doi: 10.3390/medicina56020058.
It was previously shown that a bodyweight reduction among patients with nonalcoholic fatty liver (NAFLD) was connected to the lower concentration of arachidonic and linoleic acid derivatives in their blood. We hypothesized that the concentration of these lipids was correlated with the extent of their body mass reduction and, thus, liver steatosis. We analyzed 68 individuals who completed the dietary intervention. Patients were divided into two groups depending on their body mass reduction (more or less than 7%). Before and after the dietary intervention, all patients had the following measurements recorded: body mass, waist circumference, stage of steatosis, fatty liver index, liver enzymes, lipid parameters, insulin and glucose. Concentrations of lipoxins A4 (LTX A4), hydroxyeicosatetraenoic fatty acids (5(S)-HETE, 12(S)-HETE and 16(S)-HETE), hydroxyoctadecaenoic acids (9(S)-HODE and 13(S)-HODE) and 5-oxo-eicosatetraenoic acid (5-oxo-ETE) were measured in serum samples collected before and after the dietetic intervention using high-performance liquid chromatography (HPLC). Patients who reduced their body mass by more than 7% revealed a significant improvement in their steatosis stage, waist circumference, fatty liver index, triglycerides and cholesterol. : A reduction in body mass by more than 7% but not by less than 7% revealed a significant improvement in steatosis stage; waist circumference; fatty liver index; and levels of triglycerides, cholesterol, 5-oxo-ETE and LTXA-4.
先前的研究表明，非酒精性脂肪肝 (NAFLD) 患者的体重减轻与血液中花生四烯酸和亚油酸衍生物的浓度降低有关。我们假设这些脂质的浓度与他们体重减轻的程度相关，从而与肝脂肪变性相关。我们分析了完成饮食干预的 68 名个体。根据体重减轻的程度（超过或少于 7%），将患者分为两组。在饮食干预前后，所有患者均记录了以下测量值：体重、腰围、脂肪变性程度、脂肪肝指数、肝酶、脂质参数、胰岛素和血糖。在饮食干预前后采集血清样本，使用高效液相色谱法 (HPLC) 测量血清中脂氧素 A4 (LTX A4)、羟二十碳四烯酸 (5(S)-HETE、12(S)-HETE 和 16(S)-HETE)、羟基十八碳烯酸 (9(S)-HODE 和 13(S)-HODE) 和 5-氧代二十碳四烯酸 (5-oxo-ETE) 的浓度。体重减轻超过 7%的患者其脂肪变性程度、腰围、脂肪肝指数、甘油三酯和胆固醇均显著改善。体重减轻超过 7%而非少于 7%的患者，其脂肪变性程度、腰围、脂肪肝指数、甘油三酯、胆固醇、5-oxo-ETE 和 LTXA-4 的水平均显著改善。
