Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, Szczecin 71-210, Poland.
Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin 71-210, Poland.
Int J Environ Res Public Health. 2019 Mar 20;16(6):1006. doi: 10.3390/ijerph16061006.
: The purpose of our investigation was to analyze the relationship between the serum levels of inflammatory mediators (HETE, HODE) and the levels of selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). : The study involved 151 men with BPH. Blood samples were taken for laboratory analysis of the serum levels of metabolic and hormonal parameters. Gas chromatography was performed using an Agilent Technologies 7890A GC System. : We found that waist circumference was the only parameter related to the levels of fatty acids, namely: 13(S)-HODE, 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE. In the patients with BPH and MetS, triglycerides correlated with 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE, which was not observed in the patients without MetS. Similarly, total cholesterol correlated with 9(S)-HODE, and 15(S)-HETE in the patients with BPH and MetS, but not in those without MetS. In the group of BPH patients with MetS, total testosterone positively correlated with 13(S)-HODE, and free testosterone with 9(S)-HODE. : Based on this study, it can be concluded that lipid mediators of inflammation can influence the levels of biochemical and hormonal parameters, depending on the presence of MetS in BPH patients.
: 我们的研究目的是分析炎症介质（HETE、HODE）的血清水平与患有代谢综合征（MetS）的良性前列腺增生（BPH）患者的某些代谢和激素参数水平之间的关系。 : 这项研究涉及 151 名患有 BPH 的男性。采集血液样本进行实验室分析，以检测代谢和激素参数的血清水平。使用安捷伦技术 7890A GC 系统进行气相色谱分析。 : 我们发现腰围是与脂肪酸水平相关的唯一参数，即：13(S)-HODE、9(S)-HODE、15(S)-HETE、12(S)-HETE 和 5-HETE。在患有 BPH 和 MetS 的患者中，甘油三酯与 9(S)-HODE、15(S)-HETE、12(S)-HETE 和 5-HETE 相关，而在没有 MetS 的患者中则没有观察到这种相关性。同样，总胆固醇与患有 BPH 和 MetS 的患者中的 9(S)-HODE 以及 15(S)-HETE 相关，但在没有 MetS 的患者中则没有。在患有 MetS 的 BPH 患者组中，总睾酮与 13(S)-HODE 呈正相关，游离睾酮与 9(S)-HODE 呈正相关。 : 根据这项研究，可以得出结论，炎症的脂质介质可以影响生化和激素参数的水平，具体取决于 BPH 患者是否存在 MetS。
