Deguchi Y, Negoro S, Kishimoto S
Third Department of Internal Medicine, Osaka University School of Medicine, Japan.
Biochem Biophys Res Commun. 1988 Dec 15;157(2):580-4. doi: 10.1016/s0006-291x(88)80289-4.
In this study, we show the age-related retardation of heat shock 70 kD protein (hsp 70) gene transcription in peripheral blood mononuclear cells (PBMC). The amount of maximum transcription of the hsp 70 gene is decreased in PBMC from aged subjects, compared with PBMC from young control subjects. It might mean that the ability for homeostasis against heat shock stress decreases in PBMC from aged subjects. Our observation might be at least correlative and consistent with the age-related change of a possible essential function in PBMC.
在本研究中，我们发现外周血单核细胞（PBMC）中热休克70 kD蛋白（hsp 70）基因转录随年龄增长而延迟。与年轻对照受试者的PBMC相比，老年受试者PBMC中hsp 70基因的最大转录量减少。这可能意味着老年受试者PBMC中抵抗热休克应激的稳态能力下降。我们的观察结果可能至少与PBMC中一种可能的基本功能随年龄变化相关且一致。
