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消除:纳米制剂的威力。

Eradication of : the power of nanosized formulations.

机构信息

Innovative Drug Research Center (IDRC), School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, PR China.

出版信息

Nanomedicine (Lond). 2020 Feb;15(5):527-542. doi: 10.2217/nnm-2019-0329. Epub 2020 Feb 7.

Abstract

is a pathogen that is considered to cause several gastric disorders such as chronic gastritis, peptic ulcer and even gastric carcinoma. The current therapeutic regimens mainly constitute of a combination of several antimicrobial agents and proton pump inhibitors. However, the prevalence of antibiotic resistance has been significantly lowering the cure rates over the years. Nanocarriers possess unique strengths in this regard owing to the fact that they can protect the drugs (such as antibiotics) from the harsh environment in the stomach, penetrate the mucosal barrier and deliver drugs to the desired site. In this review we summarized recent studies of different antibacterial agents orally delivered by nanosized carriers for the eradication of .

摘要

幽门螺杆菌是一种病原体,被认为会引起多种胃部疾病,如慢性胃炎、消化性溃疡,甚至胃癌。目前的治疗方案主要包括几种抗菌药物和质子泵抑制剂的联合应用。然而,抗生素耐药性的流行近年来显著降低了治愈率。纳米载体在这方面具有独特的优势,因为它们可以保护药物(如抗生素)免受胃部恶劣环境的影响,穿透黏膜屏障,并将药物递送到所需部位。在这篇综述中,我们总结了最近关于纳米载体口服递送不同抗菌剂以根除幽门螺杆菌的研究。

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