Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
BMC Geriatr. 2020 Feb 6;20(1):45. doi: 10.1186/s12877-020-1445-z.
Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits, (ii) to investigate the interaction between both motor and cognitive deficits and (iii) to assess health status as well as treatment outcome of 1000 geriatric inpatients in hospitals of Kiel (Germany), Brescia (Italy), Porto (Portugal), Curitiba (Brazil) and Bochum (Germany).
This is a prospective, explorative observational multi-center study. In addition to the comprehensive geriatric assessment, quantitative measures of reduced mobility and motor and cognitive deficits are performed before and after a two week's inpatient stay. Components of the assessment are mobile technology-based assessments of gait, balance and transfer performance, neuropsychological tests, frailty, sarcopenia, autonomic dysfunction and sensation, and questionnaires to assess behavioral deficits, activities of daily living, quality of life, fear of falling and dysphagia. Structural MRI and an unsupervised 24/7 home assessment of mobility are performed in a subgroup of participants. The study will also investigate the minimal clinically relevant change of the investigated parameters.
This study will help form a better understanding of symptoms and their complex interactions and treatment effects in a large geriatric cohort.
运动和认知功能障碍以及由此导致的行动问题在老年患者中很常见。目前用于诊断和评估这一脆弱人群治疗效果的方法有限。ComOn（老年人群的认知和运动相互作用）研究的目的是：（i）定义具有运动和认知功能障碍临床相关性的定量标志物，（ii）研究运动和认知功能障碍之间的相互作用，（iii）评估德国基尔、意大利布雷西亚、葡萄牙波尔图、巴西库里蒂巴和德国波鸿的 1000 名住院老年患者的健康状况和治疗效果。
这是一项前瞻性、探索性的多中心观察性研究。除了全面的老年评估外，还在两周住院前后对行动不便以及运动和认知功能障碍进行定量测量。评估的组成部分包括基于移动技术的步态、平衡和转移能力评估、神经心理学测试、虚弱、肌肉减少症、自主神经功能障碍和感觉、以及评估行为障碍、日常生活活动、生活质量、跌倒恐惧和吞咽困难的问卷。在一部分参与者中还进行了结构磁共振成像和 24/7 无人监督的移动性家庭评估。该研究还将调查所研究参数的最小临床相关变化。
该研究将有助于更好地理解老年患者的症状及其复杂的相互作用和治疗效果。
