Federal University of Sao Paulo (UNIFESP/ EPM). Rheumatology Division, 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, 04025-010, Brazil.
Vale do Paraiba University, 2911 Shidhima Hifumi, Avenue.Urbanova, Sao Jose dos Campos, 12244-000, Brazil.
Lipids Health Dis. 2020 Feb 7;19(1):21. doi: 10.1186/s12944-020-1200-7.
INTRODUCTION/ OBJECTIVES: Assuming that there is a link between lipid and glucose metabolism and inflammation in patients with psoriatic arthritis (PsA), our aim was to evaluate the relationships among body composition measurements, food intake, and disease activity in patients with PsA.
A total of 97 patients with PsA, according to the CASPAR criteria, were included in this cross-sectional study. Body composition measurements (whole-body DXA, GE-Lunar), food intake (3-day registry) and biochemical and inflammatory serum markers were evaluated. Skin and joint disease activity were assessed by using PASI, BSA, DAS28, and minimal disease activity (MDA). The level of significance was set as p < 0.05.
A higher prevalence of obesity, according to the fat mass index (FMI) (92.7%), and metabolic syndrome (MetS) (54%) were found, but no significant changes regarding lean or bone mass were found. Joint disease activity was positively correlated with total body fat (r = 0.4; p < 0.001), FMI (r = 0.33; p < 0.001), body mass index (r = 0.20; p < 0.049) and waist circumference (r = 0.27; p = 0.009). In addition, joint disease activity was negatively associated with muscle mass (r = - 0.38; p < 0.001). Skin disease activity was positively correlated with total cholesterol (r = 0.3; p = 0.003) and LDL-cholesterol (r = 0.28; p = 0.006). After multiple adjustments, patients with severe joint disease activity had higher body adiposity than patients in remission or with low disease activity. Skin disease activity was associated with higher trans-fat intake and lower omega-6 consumption.
Our data suggest a possible harmful link among fat (body adiposity, saturated fat consumption, LDL-cholesterol serum levels) and joint and skin disease activity in patients with PsA.
简介/目的：假设脂代谢、糖代谢和炎症之间存在联系，且在患有银屑病关节炎（PsA）的患者中也是如此，我们的目的是评估 PsA 患者的身体成分测量、饮食摄入和疾病活动之间的关系。
本横断面研究共纳入 97 名符合 CASPAR 标准的 PsA 患者。评估了身体成分测量（全身 DXA、GE-Lunar）、饮食摄入（3 天记录）和生化及炎症血清标志物。通过 PASI、BSA、DAS28 和最小疾病活动（MDA）评估皮肤和关节疾病活动。将显著性水平设定为 p<0.05。
发现肥胖（根据脂肪量指数（FMI））和代谢综合征（MetS）的患病率较高（分别为 92.7%和 54%），但瘦组织或骨量无明显变化。关节疾病活动与全身脂肪（r=0.4；p<0.001）、FMI（r=0.33；p<0.001）、体重指数（r=0.20；p<0.049）和腰围（r=0.27；p=0.009）呈正相关。此外，关节疾病活动与肌肉量呈负相关（r=-0.38；p<0.001）。皮肤疾病活动与总胆固醇（r=0.3；p=0.003）和 LDL 胆固醇（r=0.28；p=0.006）呈正相关。经过多次调整后，关节疾病活动严重的患者体脂较多，而缓解或疾病活动较低的患者体脂较少。皮肤疾病活动与较高的反式脂肪摄入和较低的欧米伽-6 消耗有关。
我们的数据表明，在患有 PsA 的患者中，脂肪（身体肥胖、饱和脂肪摄入、LDL 胆固醇血清水平）与关节和皮肤疾病活动之间可能存在有害联系。
