中国特定病因导致的肝硬化和其他慢性肝病负担：2016 年全球疾病负担研究的结果。

Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990-2016: Findings from the Global Burden of Disease Study 2016.

机构信息

Hebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 050017, Hebei, China.

National Center for Chronic and Non-communicable Disease Control and Prevention, China CDC, Beijing 100050, China.

出版信息

Biomed Environ Sci. 2020 Jan 20;33(1):1-10. doi: 10.3967/bes2020.001.

DOI:10.3967/bes2020.001

PMID:32029053

Abstract

OBJECTIVE

To estimate the burden of cirrhosis and other chronic liver diseases caused by specific etiologies in China.

METHODS

Data from the Global Burden of Disease Study 2016 (GBD 2016) were used. We evaluated the burden by analyzing age-sex-province-specific prevalence, mortality, and disability-adjusted life-years (DALYs) of 33 provinces in China.

RESULTS

From 1990 to 2016, prevalence cases in thousands increased by 73.7% from 6833.3 (95% : 6498.0-7180.6) to 11869.6 (95% : 11274.6-12504.7). Age-standardized mortality and DALY rates per 100,000 decreased by 51.2% and 53.3%, respectively. Male and elderly people (aged ≥ 60 years) preponderance were found for prevalence, mortality, and DALYs. The number of prevalence cases, deaths, and DALYs due to hepatitis C virus (HCV) increased by 86.6%, 8.7%, and 0.9%, respectively. Also, age-standardized prevalence rates decreased in 31 provinces, but increased in Yunnan and Shandong. The Socio-demographic Index (SDI) values were negatively correlated with age-standardized mortality and DALY rates by provinces in 2016; the correlation coefficients were -0.817 and -0.828, respectively.

CONCLUSION

Cirrhosis and other chronic liver diseases remain a huge health burden in China, with the increase of population and the aging of population. Hepatitis B virus (HBV) remains the leading cause of the health burden in China.

摘要

目的

估计中国特定病因导致的肝硬化和其他慢性肝病的负担。

方法

使用 2016 年全球疾病负担研究（GBD 2016）的数据。我们通过分析中国 33 个省份的年龄-性别-省份特异性流行率、死亡率和伤残调整生命年（DALY）来评估负担。

结果

从 1990 年到 2016 年，中国的流行病例数以千计增加了 73.7%，从 6833.3（95%置信区间：6498.0-7180.6）增加到 11869.6（95%置信区间：11274.6-12504.7）。每 100000 人标准化死亡率和 DALY 率分别下降了 51.2%和 53.3%。流行率、死亡率和 DALY 以男性和老年人（年龄≥60 岁）为主。丙型肝炎病毒（HCV）导致的流行病例数、死亡人数和 DALY 分别增加了 86.6%、8.7%和 0.9%。此外，2016 年 31 个省份的标准化流行率下降，而云南和山东则有所上升。2016 年，各省的社会人口指数（SDI）值与标准化死亡率和 DALY 率呈负相关；相关系数分别为-0.817 和-0.828。