中国特定病因导致的病毒性肝炎负担，1990-2016 年：来自 GBD 2016 的发现。
Burden of viral hepatitis caused by specific aetiologies in China, 1990-2016: findings from the GBD 2016.
机构信息
Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang, 050017, Shijiazhuang, People's Republic of China.
Hebei Province Key Laboratory of Environment and Human Health, Shijiazhuang, China.
出版信息
BMC Public Health. 2020 Sep 29;20(1):1461. doi: 10.1186/s12889-020-09533-4.
BACKGROUND
The aim of this study is to quantify the burden caused by viral hepatitis in China from 1990 to 2016.
METHODS
Data from the GBD 2016 study were extracted to calculate incidence, prevalence and disability-adjusted life years (DALYs). Trends in DALYs were assessed in 33 provinces/regions.
RESULTS
From 1990 to 2016, the total incidence of hepatitis decreased by 88.5%. However, the prevalence of hepatitis (counts in thousands), increased by 37.6% from 153,856 (95% UI: 136,047-172,319) in 1990 to 211,721 (95% UI: 179,776-240,981) in 2016, with age-standardized prevalence rates changing slightly. The number and age-standardized rates of prevalence increased by 35.9 and 1.6% for hepatitis B, respectively, and by 81.8 and 30.4% for hepatitis C. Guangxi, Guangdong and Hainan had the highest age-standardized prevalence rates (≥16,500 per 100,000). Tibet, Qinghai and Gansu had the highest age-standardized DALYs rates (≥40 per 100,000). The largest absolute number of DALYs was observed in the 15-49 year age group in 2016. The highest rate of DALYs occurred in males aged 50-69 years and in females aged ≧70 years.
CONCLUSION
The incidence and DALYs of viral hepatitis decreased dramatically from 1990 to 2016. However, the prevalence still remains at a high level, which may result in heavy burdens in the future.
背景
本研究旨在量化 1990 年至 2016 年中国病毒性肝炎的负担。
方法
从 GBD 2016 研究中提取数据以计算发病率、患病率和伤残调整生命年（DALYs）。评估了 33 个省/自治区的 DALYs 趋势。
结果
1990 年至 2016 年，肝炎总发病率下降了 88.5%。然而，肝炎的患病率（以千计）从 1990 年的 153856（95%置信区间：136047-172319）增加到 2016 年的 211721（95%置信区间：179776-240981），增长了 37.6%，年龄标准化患病率略有变化。乙型肝炎的数量和年龄标准化率分别增加了 35.9%和 1.6%，丙型肝炎分别增加了 81.8%和 30.4%。广西、广东和海南的年龄标准化患病率最高（≥16500/10 万）。西藏、青海和甘肃的年龄标准化 DALYs 率最高（≥40/10 万）。2016 年，15-49 岁年龄组的 DALYs 绝对数量最大。DALYs 发生率最高的是 50-69 岁男性和≥70 岁女性。
结论
1990 年至 2016 年，病毒性肝炎的发病率和 DALYs 急剧下降。然而，患病率仍处于较高水平，未来可能会造成沉重负担。
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