Hrafnkelsson J, Stål O, Eneström S, Jonasson J G, Björnsson J, Olafsdottir K, Nordenskjöld B
Department of Oncology, Regional Hospital, Linköping, Sweden.
Acta Oncol. 1988;27(4):329-33. doi: 10.3109/02841868809093550.
A series of 150 patients with papillary thyroid cancer diagnosed in Iceland during the 30-year period from 1955 through 1984 was retrospectively analyzed. Flow cytometric analysis of archival paraffin-embedded material was used to study the prognostic significance of cellular DNA content and s-phase frequency. DNA-aneuploidy was found in 12% of the tumors. It was significantly more common in the elderly, in moderately and poorly differentiated carcinomas, in males and in tumors with a high proportion of s-phase cells. Multivariate analysis using stepwise Cox's model showed aneuploidy, age at diagnosis, lymph node metastasis and tumor extension beyond the thyroid capsule as independent prognostic factors. The frequency of cells in s-phase was generally low (mean 2.7%). Patients with high s-phase frequency (greater than 2.5%) had less favorable prognosis than patients with low values (less than or equal to 2.5%).
对1955年至1984年这30年间在冰岛诊断出的150例甲状腺乳头状癌患者进行了回顾性分析。利用存档石蜡包埋材料进行流式细胞术分析，以研究细胞DNA含量和S期频率的预后意义。在12%的肿瘤中发现了DNA非整倍体。在老年人、中低分化癌、男性以及S期细胞比例高的肿瘤中更为常见。使用逐步Cox模型进行多变量分析显示，非整倍体、诊断时年龄、淋巴结转移和肿瘤超出甲状腺包膜的范围是独立的预后因素。S期细胞的频率通常较低（平均2.7%）。S期频率高（大于2.5%）的患者预后比S期频率低（小于或等于2.5%）的患者差。
