Abuduhalike Refukaiti, Sun Juan, Zhao Li, Mahemuti Ailiman
Cardiovascular Department, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, China.
J Thorac Dis. 2019 Dec;11(12):5527-5534. doi: 10.21037/jtd.2019.11.26.
The relationship between inflammation and venous thromboembolism (VTE) has not been fully elucidated.
Based on our previous studies, we detected the plasma levels of serum amyloid A protein (SAA), interleukin-1 (IL-1), and tumor necrosis factor-a (TNF-a) and their 8 gene polymorphisms by ELISA and a multiplex ligation detection reaction (iMLDR) method in 284 patients with VTE and 268 healthy controls.
Levels of SAA (P=0.032), IL-1 (P=0.045), and TNF-a (P=0.040) were significantly higher in the VTE group than in the control group. Recessive model analysis of the IL-1 rs1800587 variant showed that the risk of VTE in patients with the GG + GA genotype was significantly higher than that in patients with the AA genotype [odds ratio (OR): 4.444; 95% CI: 1.466-13.470]. Recessive model analysis of the IL-1 rs2234650 polymorphism showed that the risk of VTE in patients with the CC + CT genotype was significantly lower than that in patients with the TT genotype (OR: 0.500; 95% CI: 0.268-0.934). Multivariate logistic regression analysis showed that the TT genotype at IL-1 rs2234650 (OR: 2.086; 95% CI: 1.091-3.985) was an independent risk factor for VTE. The AA genotype of IL-1 rs1800587 (OR: 0.226; 95% CI: 0.074-0.890) was an independent protective factor against VTE.
In summary, an intrinsic relationship may exist between inflammatory activation and the occurrence of VTE.
炎症与静脉血栓栓塞症（VTE）之间的关系尚未完全阐明。
基于我们之前的研究，我们采用酶联免疫吸附测定（ELISA）和多重连接检测反应（iMLDR）方法，检测了284例VTE患者和268例健康对照者的血清淀粉样蛋白A（SAA）、白细胞介素-1（IL-1）和肿瘤坏死因子-α（TNF-α）的血浆水平及其8种基因多态性。
VTE组的SAA（P = 0.032）、IL-1（P = 0.045）和TNF-α（P = 0.040）水平显著高于对照组。对IL-1 rs1800587变异体的隐性模型分析显示，GG + GA基因型患者发生VTE的风险显著高于AA基因型患者[比值比（OR）：4.444；95%置信区间（CI）：1.466 - 13.470]。对IL-1 rs2234650多态性的隐性模型分析显示，CC + CT基因型患者发生VTE的风险显著低于TT基因型患者（OR：0.500；95% CI：0.268 - 0.934）。多因素逻辑回归分析显示，IL-1 rs2234650的TT基因型（OR：2.086；95% CI：1.091 - 3.985）是VTE的独立危险因素。IL-1 rs1800587的AA基因型（OR：0.226；95% CI：0.074 - 0.890）是预防VTE的独立保护因素。
总之，炎症激活与VTE的发生之间可能存在内在关系。
