Yadav Umesh, Mahemuti Ailiman, Hu Xuemei, Abudureheman Kailibinure, Xia Yuning, Tang Baopeng, Upur Halmurat
Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Mol Med Rep. 2015 Jun;11(6):4664-70. doi: 10.3892/mmr.2015.3248. Epub 2015 Jan 26.
The aim of the present study was to reveal the contribution of single nucleotide polymorphisms of the interleukin‑6 (IL‑6) gene and the progression of venous thromboembolism (VTE). A case‑control study composed of 246 VTE patients, including 160 from the Han population (76 males and 84 females, mean age 57.41±13.25 years), 86 from the Uyghur population (41 males and 45 females, mean age 51.61±13.73 years) and 292 gender and ethnicity‑matched control participants, including 170 from the Han population (91 males and 79 females, mean age 55.82±11.83 years) and 122 from the Uyghur population (64 males and 58 females, mean age 53.52±13.64 years) were enrolled in the present study. The results demonstrated that the serum levels of IL‑6, C‑reactive protein (CRP), D‑dimer, fibrinogen, plasminogen activator inhibitor‑1 and leptin were significantly higher in the VTE group compared with the control group (P<0.05). The frequencies of the ‑572C/G promoter polymorphisms of the IL‑6 genotypes CC, CG and GG were identified to be 34, 48 and 18% in the Han population and 33, 47 and 20% in the Uyghur population, respectively. The allele frequency distributions of the C and G alleles were 58 and 42% in the Han population and 56 and 43% in the Uyghur population, respectively. Significant differences were identified in the ‑572C/G promoter polymorphisms between the VTE group and the control group (P<0.05). For the ‑597G/A polymorphism, all individuals carried the GG and GA genotype; AA genotypes were not detected. Logistic regression analysis was used to identify the risk factors for VTE, adjusting by confounding factors, the results of which demonstrated that the CC homozygote of the IL‑6 ‑572G/C, CRP, IL‑6 and high‑density lipoprotein‑cholesterol were independent risk factors of VTE (P<0.05). In conclusion, the ‑572G/C genotype of IL‑6 may be a genetic marker of VTE in the Han and Uyghur populations.
本研究的目的是揭示白细胞介素-6（IL-6）基因单核苷酸多态性与静脉血栓栓塞症（VTE）进展之间的关系。本研究纳入了一项病例对照研究，其中包括246例VTE患者，其中汉族160例（男性76例，女性84例，平均年龄57.41±13.25岁），维吾尔族86例（男性41例，女性45例，平均年龄51.61±13.73岁），以及292例性别和种族匹配的对照参与者，其中汉族170例（男性91例，女性79例，平均年龄55.82±11.83岁），维吾尔族122例（男性64例，女性58例，平均年龄53.52±13.64岁）。结果表明，与对照组相比，VTE组的IL-6、C反应蛋白（CRP）、D-二聚体、纤维蛋白原、纤溶酶原激活物抑制剂-1和瘦素的血清水平显著升高（P<0.05）。IL-6基因型CC、CG和GG的-572C/G启动子多态性频率在汉族人群中分别为34%、48%和18%，在维吾尔族人群中分别为33%、47%和20%。C和G等位基因的频率分布在汉族人群中分别为58%和42%，在维吾尔族人群中分别为56%和43%。VTE组与对照组之间的-572C/G启动子多态性存在显著差异（P<0.05）。对于-597G/A多态性，所有个体均携带GG和GA基因型；未检测到AA基因型。采用逻辑回归分析确定VTE的危险因素，并对混杂因素进行校正，结果表明IL-6 -572G/C的CC纯合子、CRP、IL-6和高密度脂蛋白胆固醇是VTE的独立危险因素（P<0.05）。总之，IL-6的-572G/C基因型可能是汉族和维吾尔族人群中VTE的遗传标志物。
