Pullar T, Myall O, Haigh J R, Lowe J R, Dixon J S, Bird H A
Department of Medicine, University of Leeds.
Br J Clin Pharmacol. 1988 Jun;25(6):755-7. doi: 10.1111/j.1365-2125.1988.tb05263.x.
The effect of 5 days treatment with allopurinol (300 mg) on the pharmacokinetics of indomethacin at steady-state was investigated in eight patients. Allopurinol produced no significant effect on the indomethacin serum concentration-time curve. Allopurinol did not alter significantly the amounts of indomethacin excreted in the urine within 8 h. However, the urinary ratio of N-deschlorobenzoylindomethacin to indomethacin was reduced significantly by allopurinol administration (P less than 0.05).
在8名患者中研究了用别嘌醇（300毫克）治疗5天对稳态下吲哚美辛药代动力学的影响。别嘌醇对吲哚美辛血清浓度-时间曲线无显著影响。别嘌醇对8小时内尿液中排出的吲哚美辛量无显著改变。然而，给予别嘌醇后，N-去氯苯甲酰基吲哚美辛与吲哚美辛的尿排泄比显著降低（P<0.05）。
