Köhler G, Dell H D, Kamp R
Z Rheumatol. 1981 Mar-Apr;40(2):97-9.
Non-steroidal antiinflammatory drugs (NSAID) are indispensable for modern treatment of rheumatoid arthritis. Reports on drug concentration in rheumatoid human tissues are still lacking. We now report about steady-state concentrations of Indomethacin and Acemetacin in blood, synovial fluid, synovial membrane, muscle, bone and fat 6h after the last application of Acemetacin resp. Indomethacin. Levels in all tissues, except fat, were found to be significantly higher than in blood. Therefore, a noticeable accumulation of drug occurs in all rheumatoid tissues.
非甾体抗炎药（NSAID）是现代类风湿关节炎治疗中不可或缺的药物。目前仍缺乏关于类风湿患者组织中药物浓度的报道。我们现在报告在最后一次应用阿西美辛或吲哚美辛6小时后，血液、滑液、滑膜、肌肉、骨骼和脂肪中吲哚美辛和阿西美辛的稳态浓度。除脂肪外，所有组织中的药物浓度均显著高于血液中的浓度。因此，在所有类风湿组织中均出现了明显的药物蓄积。
